Reactome | His3.3A [nucleoplasm]

His3.3A [nucleoplasm]

Stable Identifier

R-DME-427324

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

Me2K-10-H3F3A, C0HL66

Locations in the PathwayBrowser

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Cellular responses to stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Cellular Senescence (Drosophila melanogaster)
    - Senescence-Associated Secretory Phenotype (SASP) (Drosophila melanogaster)
      - EHMT1:EHMT2 methylates IL6 promoter (Drosophila melanogaster)
        
        IL6 gene:Nucleosome-H3K9Me2 [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)
      - EHMT1:EHMT2 methylates IL8 promoter (Drosophila melanogaster)
        
        IL8 gene:Nucleosome-H3K9Me2 [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)

Gene expression (Transcription) (Drosophila melanogaster)

- Epigenetic regulation of gene expression (Drosophila melanogaster)
  - Negative epigenetic regulation of rRNA expression (Drosophila melanogaster)
    - NoRC negatively regulates rRNA expression (Drosophila melanogaster)
      - MBD2 binds methylcytosine in chromatin (Drosophila melanogaster)
        
        Chromatin (H3K9me2, 5mC):MBD2 [nucleoplasm] (Drosophila melanogaster)
        
        Chromatin with H3K9me2, 5mC [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)
        
        Chromatin with H3K9me2, 5mC [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)
    - SIRT1 negatively regulates rRNA expression (Drosophila melanogaster)
      - Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Drosophila melanogaster)
        
        Chromatin (H3K9me2) [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)
        
        eNoSC [nucleoplasm] (Drosophila melanogaster)
        
        Chromatin (H3K9me2) [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)
      - eNoSC deacetylates histone H3 (Drosophila melanogaster)
        
        eNoSC [nucleoplasm] (Drosophila melanogaster)
        
        Chromatin (H3K9me2) [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)
      - eNoSC dimethylates histone H3 at lysine-9 (Drosophila melanogaster)
        
        Chromatin (H3K9me2) [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)
        
        eNoSC [nucleoplasm] (Drosophila melanogaster)
        
        Chromatin (H3K9me2) [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)
- RNA Polymerase I Transcription (Drosophila melanogaster)
  - RNA Polymerase I Promoter Clearance (Drosophila melanogaster)
    - RNA Polymerase I Promoter Escape (Drosophila melanogaster)
      - Elongation of pre-rRNA transcript (Drosophila melanogaster)
        
        Chromatin (H3K9me2):CBX3 [nucleoplasm] (Drosophila melanogaster)
        
        Chromatin (H3K9me2) [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by Nuclear Receptors (Drosophila melanogaster)
  - ESR-mediated signaling (Drosophila melanogaster)
    - Estrogen-dependent gene expression (Drosophila melanogaster)
      - KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Drosophila melanogaster)
        
        MYC gene, BCL2 gene: H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG:KDM1A [nucleoplasm] (Drosophila melanogaster)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)
      - KDM1A is recruited to MYC and BCL2 genes (Drosophila melanogaster)
        
        MYC gene, BCL2 gene: H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG:KDM1A [nucleoplasm] (Drosophila melanogaster)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:C0HL66

Gene Names

His3.3A

Reference Genes

BioGPS Gene:33736 His3.3A

ENSEMBL:FBgn0014857

FlyBase:FBgn0014857

KEGG:dme:Dmel_CG5825 His3.3B

KEGG:dme:Dmel_CG8989 His3.3B

Monarch:33736 His3.3A

NCBI Gene:33736 His3.3A

UCSC:C0HL66 His3.3A

Reference Transcript

Other Identifiers

142668_at

143766_i_at

143767_r_at

1623222_s_at

1627685_a_at

31848

33736

GO:0000786

GO:0003677

GO:0005198

GO:0005634

GO:0005694

GO:0005700

GO:0006325

GO:0006334

GO:0030527

GO:0046982

GO:0065003

Participates

as a member of

Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

His3.3A [nucleoplasm]

phospho-His3.3A [nucleoplasm]

His3.3A [nucleoplasm]

phospho-His3.3A [nucleoplasm]

His3.3A [nucleoplasm]

Inferred From

Me2K-10-H3F3A [nucleoplasm] (Homo sapiens)

Modified Residues

Name

N6,N6-dimethyl-L-lysine at 10 (in Homo sapiens)

Coordinate

PsiMod Name

N6,N6-dimethyl-L-lysine [MOD:00084]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine.

Cross References

RefSeq

NP_001260082.1, NP_523479.1, NP_723056.2

ENSEMBL

FBpp0309302, FBtr0333537, FBtr0071345, FBtr0071347, FBtr0333536, FBgn0004828, FBtr0079010, FBpp0305716, FBpp0305717, FBgn0014857, FBpp0078649, FBpp0071280, FBpp0071282, FBpp0071281, FBtr0340343, FBtr0071346

FlyBase

FBgn0014857

PRO

C0HL66

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