Reactome | His3.3A [nucleoplasm]

His3.3A [nucleoplasm]

Stable Identifier

R-DME-1214216

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

Me3K5-H3F3A, C0HL66

Locations in the PathwayBrowser

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Chromatin organization (Drosophila melanogaster)

- ATP-dependent chromatin remodelers (Drosophila melanogaster)
  - CHD chromatin remodelers (Drosophila melanogaster)
    - CHD1 and CHD2 subfamily (Drosophila melanogaster)
      - CHD1 and CHD2 bind H3K4me3 nucleosomes (Drosophila melanogaster)
        
        CHD1,CHD2:H3K4me3 chromatin [nucleoplasm] (Drosophila melanogaster)
        
        chromatin with H3K4me3 nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 (H3K4me3) [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me3K5-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)
        
        chromatin with H3K4me3 nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 (H3K4me3) [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me3K5-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)
      - CHD1:H3K4me3 interacts with post-initiation transcription complexes (Drosophila melanogaster)
        
        CHD1:H3K4 nucleosome:FACT complex:U2 snRNP complex:PAF1C complex [nucleoplasm] (Drosophila melanogaster)
        
        CHD1:H3K4me3 chromatin [nucleoplasm] (Drosophila melanogaster)
        
        chromatin with H3K4me3 nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 (H3K4me3) [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me3K5-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)
        
        CHD1:H3K4me3 chromatin [nucleoplasm] (Drosophila melanogaster)
        
        chromatin with H3K4me3 nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 (H3K4me3) [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me3K5-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)

Immune System (Drosophila melanogaster)

- Adaptive Immune System (Drosophila melanogaster)
  - Regulation of T cell activation by CD28 family (Drosophila melanogaster)
    - Co-inhibition by PD-1 (Drosophila melanogaster)
      - Regulation of PD-L1(CD274) expression (Drosophila melanogaster)
        
        Regulation of PD-L1(CD274) transcription (Drosophila melanogaster)
        
        Trimethylation of CD274 gene chromatin by MLL1/3 complex (Drosophila melanogaster)
        
        MLL1,MLL3_complex:CD274 gene H3K4me3 chromatin [nucleoplasm] (Drosophila melanogaster)
        
        CD274 gene H3K4me3 chromatin [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 (H3K4me3) [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me3K5-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:C0HL66

Gene Names

His3.3A

Reference Genes

BioGPS Gene:33736 His3.3A

ENSEMBL:FBgn0014857

FlyBase:FBgn0014857

KEGG:dme:Dmel_CG5825 His3.3B

KEGG:dme:Dmel_CG8989 His3.3B

Monarch:33736 His3.3A

NCBI Gene:33736 His3.3A

UCSC:C0HL66 His3.3A

Reference Transcript

Other Identifiers

142668_at

143766_i_at

143767_r_at

1623222_s_at

1627685_a_at

31848

33736

GO:0000786

GO:0003677

GO:0005198

GO:0005634

GO:0005694

GO:0005700

GO:0006325

GO:0006334

GO:0030527

GO:0046982

GO:0065003

Participates

as a member of

Homologues of Me3K5-H3F3A [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

His3.3A [nucleoplasm]

phospho-His3.3A [nucleoplasm]

His3.3A [nucleoplasm]

phospho-His3.3A [nucleoplasm]

His3.3A [nucleoplasm]

Inferred From

Me3K5-H3F3A [nucleoplasm] (Homo sapiens)

Modified Residues

Name

N6,N6,N6-trimethyl-L-lysine at 5 (in Homo sapiens)

Coordinate

PsiMod Name

N6,N6,N6-trimethyl-L-lysine [MOD:00083]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine.

Cross References

RefSeq

NP_001260082.1, NP_523479.1, NP_723056.2

ENSEMBL

FBpp0309302, FBtr0333537, FBtr0071345, FBtr0071347, FBtr0333536, FBgn0004828, FBtr0079010, FBpp0305716, FBpp0305717, FBgn0014857, FBpp0078649, FBpp0071280, FBpp0071282, FBpp0071281, FBtr0340343, FBtr0071346

FlyBase

FBgn0014857

PRO

C0HL66

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