Reactome | His3.3A [nucleoplasm]

His3.3A [nucleoplasm]

Stable Identifier

R-DME-212282

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

Me3K-28-H3F3A, C0HL66

Locations in the PathwayBrowser

Expand all

Cell-Cell communication (Drosophila melanogaster)

- Cell junction organization (Drosophila melanogaster)
  - Cell-cell junction organization (Drosophila melanogaster)
    - Adherens junctions interactions (Drosophila melanogaster)
      - Regulation of Homotypic Cell-Cell Adhesion (Drosophila melanogaster)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Drosophila melanogaster)
        
        Regulation of CDH1 Expression and Function (Drosophila melanogaster)
        
        Regulation of CDH1 Gene Transcription (Drosophila melanogaster)
        
        Negative Regulation of CDH1 Gene Transcription (Drosophila melanogaster)
        
        PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter (Drosophila melanogaster)
        
        PRC2 (EZH2) Core:H3K27me3-Nucleosome:CDH1 gene [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 (H3K27me3) [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me3K-28-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)

Cellular responses to stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Cellular Senescence (Drosophila melanogaster)
    - Oxidative Stress Induced Senescence (Drosophila melanogaster)
      - KDM6B demethylates H3K27me3 on p16INK4A promoter (Drosophila melanogaster)
        
        CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 (H3K27me3) [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me3K-28-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)
      - PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Drosophila melanogaster)
        
        CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 (H3K27me3) [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me3K-28-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)
        
        CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Drosophila melanogaster)
        
        CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 (H3K27me3) [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me3K-28-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)
      - PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Drosophila melanogaster)
        
        CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 (H3K27me3) [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me3K-28-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)
      - p-MAPKAPK3 phosphorylates BMI1 (Drosophila melanogaster)
        
        CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 (H3K27me3) [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me3K-28-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)
        
        CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Drosophila melanogaster)
        
        CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 (H3K27me3) [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me3K-28-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)

Gene expression (Transcription) (Drosophila melanogaster)

- Epigenetic regulation of gene expression (Drosophila melanogaster)
  - PRC2 methylates histones and DNA (Drosophila melanogaster)
    - DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Drosophila melanogaster)
      - DNMT1,3A,3B:PRC2:Chromatin (5-mC, H3K27me3) [nucleoplasm] (Drosophila melanogaster)
        
        PRC2:Chromatin (5-methylcytosine, H3K27me3) [nucleoplasm] (Drosophila melanogaster)
        
        Chromatin with hemimethylC, H3K27me3 [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 (H3K27me3) [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me3K-28-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)
    - PRC2 trimethylates histone H3 at lysine-27 (Drosophila melanogaster)
      - PRC2:Chromatin (H3K27me3) [nucleoplasm] (Drosophila melanogaster)
        
        Chromatin with trimethylated H3K27 [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 (H3K27me3) [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me3K-28-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        His3.3A [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:C0HL66

Gene Names

His3.3A

Reference Genes

BioGPS Gene:33736 His3.3A

ENSEMBL:FBgn0014857

FlyBase:FBgn0014857

KEGG:dme:Dmel_CG5825 His3.3B

KEGG:dme:Dmel_CG8989 His3.3B

Monarch:33736 His3.3A

NCBI Gene:33736 His3.3A

UCSC:C0HL66 His3.3A

Reference Transcript

Other Identifiers

142668_at

143766_i_at

143767_r_at

1623222_s_at

1627685_a_at

31848

33736

GO:0000786

GO:0003677

GO:0005198

GO:0005634

GO:0005694

GO:0005700

GO:0006325

GO:0006334

GO:0030527

GO:0046982

GO:0065003

Participates

as a member of

Homologues of Me3K-28-H3F3A [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

His3.3A [nucleoplasm]

phospho-His3.3A [nucleoplasm]

His3.3A [nucleoplasm]

phospho-His3.3A [nucleoplasm]

His3.3A [nucleoplasm]

Inferred From

Me3K-28-H3F3A [nucleoplasm] (Homo sapiens)

Modified Residues

Name

N6,N6,N6-trimethyl-L-lysine at 28 (in Homo sapiens)

Coordinate

PsiMod Name

N6,N6,N6-trimethyl-L-lysine [MOD:00083]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine.

Cross References

RefSeq

NP_001260082.1, NP_523479.1, NP_723056.2

ENSEMBL

FBpp0309302, FBtr0333537, FBtr0071345, FBtr0071347, FBtr0333536, FBgn0004828, FBtr0079010, FBpp0305716, FBpp0305717, FBgn0014857, FBpp0078649, FBpp0071280, FBpp0071282, FBpp0071281, FBtr0340343, FBtr0071346

FlyBase

FBgn0014857

PRO

C0HL66

Cite Us!