Ubiquitination of DLL/JAG ligands upon binding to NOTCH3

Stable Identifier
R-HSA-9013069
Type
Reaction
Species
Homo sapiens
Compartment
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Based on an analogy with NOTCH1 and NOTCH2, and on studies of Drosophila Notch, NOTCH ligands DLL1, DLL4, JAG1 and JAG2 are assumed to undergo ubiquitination and endocytosis after binding to NOTCH3 in trans. Ubiquitination of DLL/JAG ligands in mammals is performed by orthologues of Drosophila Mindbomb, MIB1, possibly MIB2, and possibly orthologues of Drosophila Neuralized, NEURL and NEURL1B.

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Event Information
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Catalyst Activity

ubiquitin-protein transferase activity of MIB/NEURL [cytosol]

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