ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane

Stable Identifier
R-DME-209141
Type
Reaction [dissociation]
Species
Drosophila melanogaster
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane
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On binding to the Toll (TL) receptor ectodomain, Spatzle (SPZ) dimer sheds its Pro-domains. The SPZ dimer binds to the TL ectodomain at its N-terminus.
Literature References
PubMed ID Title Journal Year
17324925 Role of the Spatzle Pro-domain in the generation of an active toll receptor ligand

Weber, AN, Gangloff, M, Moncrieffe, MC, Hyvert, Y, Imler, JL, Gay, NJ

J Biol Chem 2007
18347020 Structural insight into the mechanism of activation of the Toll receptor by the dimeric ligand Spätzle

Gangloff, M, Murali, A, Xiong, J, Arnot, CJ, Weber, AN, Sandercock, AM, Robinson, CV, Sarisky, R, Holzenburg, A, Kao, C, Gay, NJ

J Biol Chem 2008
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Authored
Williams, MG  (2007-07-11)
Reviewed
Silverman, N  (2008-06-20)
Lemaitre, B  (2008-06-20)
Created
Williams, MG  (2007-07-12)
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