Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Formation of the trans-membrane 'signalling complex'
Stable Identifier
R-DME-209442
Type
Pathway
Species
Drosophila melanogaster
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Drosophila signaling pathways (Drosophila melanogaster)
Toll pathway (Drosophila melanogaster)
Formation of the trans-membrane 'signalling complex' (Drosophila melanogaster)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this pathway in the Pathway Browser
Spatzle (SPZ) dimer binding leads to Toll (TL) receptor homodimerisation and activation.
Literature References
PubMed ID
Title
Journal
Year
15229471
The road to Toll
Lemaitre, B
Nat Rev Immunol
2004
15199954
The immune response of Drosophila melanogaster
Leclerc, V
,
Reichhart, JM
Immunol Rev
2004
Participants
Events
Full-length GD is cleaved by an unknown protease
(Drosophila melanogaster)
Full-length SNK is cleaved by GD serine protease
(Drosophila melanogaster)
Full-length EA is cleaved by SNK serine protease
(Drosophila melanogaster)
Full-length SPZ dimer is cleaved by EA/SPE serine protease
(Drosophila melanogaster)
SPN27A binds to and inhibits EA protease activity
(Drosophila melanogaster)
ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane
(Drosophila melanogaster)
SPZ dimer bound TL dimerises at the plasma membrane
(Drosophila melanogaster)
MYD88 binds to TUB
(Drosophila melanogaster)
Adaptor protein complex binds to TL receptor at the plasma membrane
(Drosophila melanogaster)
PLL kinase binds to TUB in the TL receptor 'signalling complex'
(Drosophila melanogaster)
Participates
as an event of
Toll pathway (Drosophila melanogaster)
Authored
Williams, MG (2007-07-11)
Reviewed
Lemaitre, B (2008-06-20)
Silverman, N (2008-06-20)
Created
Williams, MG (2007-07-12)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text