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TL [plasma membrane]
Stable Identifier
R-DME-206218
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Drosophila signaling pathways (Drosophila melanogaster)
Toll pathway (Drosophila melanogaster)
Degradation of NF-kappa-B inhibitor, CACT (Drosophila melanogaster)
Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex' (Drosophila melanogaster)
Activated PLL kinase is autophosphorylated in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:PLL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
Activated PLL kinase is autophosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:PLL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' (Drosophila melanogaster)
DL dimer binds to TUB and phosphorylated PLL in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:DL dimer:CACT [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
DL/DIF dimer binds to TUB and phosphorylated PLL in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL:DL/DIF dimer:CACT [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex' (Drosophila melanogaster)
CACT and DL dimer are phosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:DL dimer:CACT [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:Phospho DL dimer:Phospho CACT [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
CACT and DL/DIF dimer are phosphorylated in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL:DL/DIF dimer:CACT [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL:Phospho DL/DIF dimer:Phospho CACT [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex' (Drosophila melanogaster)
Phosphorylated CACT and DL dimer dissociate from the TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:Phospho DL dimer:Phospho CACT [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
Phosphorylated CACT and DL/DIF dimer dissociate from the TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL:Phospho DL/DIF dimer:Phospho CACT [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
Formation of the trans-membrane 'signalling complex' (Drosophila melanogaster)
Adaptor protein complex binds to TL receptor at the plasma membrane (Drosophila melanogaster)
MYD88:TUB binds to TL receptor (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
WEK and MYD88:TUB bind to the TL receptor (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:WEK dimer:MYD88:TUB [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
PLL kinase binds to TUB in the TL receptor 'signalling complex' (Drosophila melanogaster)
PLL kinase binds to TL:MYD88:TUB 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:PLL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
PLL kinase binds to TL:WEK:MYD88:TUB 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:WEK dimer:MYD88:TUB [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:PLL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer bound TL dimerises at the plasma membrane (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
TL [plasma membrane] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P08953 Tl
Gene Names
Tl, CG5490
Chain
signal peptide:1-27, chain:28-1097
Reference Genes
BioGPS Gene:43222 Tl
KEGG Gene (Drosophila melanogaster):Dmel_CG5490 Tl
Monarch:43222 Tl
NCBI Gene:43222 Tl
Reference Transcript
RefSeq:NM_170287.3 Tl
RefSeq:NM_079794.3 Tl
Other Identifiers
151935_at
1639321_s_at
43222
GO:0002224
GO:0002225
GO:0002229
GO:0002347
GO:0002376
GO:0002804
GO:0003824
GO:0004888
GO:0004896
GO:0005515
GO:0005737
GO:0005768
GO:0005769
GO:0005886
GO:0006351
GO:0006355
GO:0006955
GO:0007155
GO:0007165
GO:0007416
GO:0007507
GO:0007526
GO:0008063
GO:0009597
GO:0009611
GO:0009897
GO:0009950
GO:0009986
GO:0016020
GO:0016043
GO:0016201
GO:0016787
GO:0019221
GO:0019955
GO:0023052
GO:0030154
GO:0030308
GO:0031410
GO:0032154
GO:0034330
GO:0035208
GO:0035212
GO:0038023
GO:0040011
GO:0040015
GO:0042802
GO:0043226
GO:0045087
GO:0045944
GO:0046627
GO:0046790
GO:0048856
GO:0050135
GO:0050830
GO:0050896
GO:0060089
GO:0061760
GO:0061809
GO:0070976
GO:0098542
GO:1902875
Participates
as a component of
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
as an input of
ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane (Drosophila melanogaster)
Other forms of this molecule
Tl [secretory granule membrane]
Tl [plasma membrane]
Tl [plasma membrane]
Tl [plasma membrane]
Tl [plasma membrane]
Cross References
RefSeq
NP_733166.1
,
NP_524518.1
Flybase
FBgn0262473
PRO
P08953
PDB
4LXR
,
4ARN
,
4LXS
,
4ARR
,
4BV4
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08953 Tl
6
TL [plasma membrane]
(R-DME-206218)
Tl [secretory granule membrane]
(R-DME-6804777)
Tl [plasma membrane]
(R-DME-167926)
Tl [plasma membrane]
(R-DME-166045)
Tl [plasma membrane]
(R-DME-168061)
Tl [plasma membrane]
(R-DME-167992)
0.609
2
UniProt:Q7K105 Myd88
2
MYD88 [cytosol]
(R-DME-206015)
Myd88 [cytosol]
(R-DME-166059)
0.589
3
UniProt:P48607 spz
3
ProSPZ [extracellular region]
(R-DME-205949)
SPZ [extracellular region]
(R-DME-205948)
SPZ full-length [extracellular region]
(R-DME-205964)
0.534
2
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