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SCF-beta-TRCP [cytosol]
Stable Identifier
R-HSA-5607687
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)
SCF-beta-TRCP [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
NIK-->noncanonical NF-kB signaling (Homo sapiens)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Homo sapiens)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Homo sapiens)
SCF-beta-TRCP [cytosol] (Homo sapiens)
SCF-beta-TRCP [cytosol] (Homo sapiens)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Homo sapiens)
SCF-beta-TRCP [cytosol] (Homo sapiens)
SCF-beta-TRCP [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
Dectin-1 mediated noncanonical NF-kB signaling (Homo sapiens)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Homo sapiens)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Homo sapiens)
SCF-beta-TRCP [cytosol] (Homo sapiens)
SCF-beta-TRCP [cytosol] (Homo sapiens)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Homo sapiens)
SCF-beta-TRCP [cytosol] (Homo sapiens)
SCF-beta-TRCP [cytosol] (Homo sapiens)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)
SCF-beta-TRCP [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated NF-kB activation (Homo sapiens)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)
SCF-beta-TRCP [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
10023660
The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin
Chiaur, DS
,
Latres, E
,
Pagano, M
Oncogene
1999
Participants
components
beta-TrCP [cytosol]
(Homo sapiens)
CUL1 [cytosol]
(Homo sapiens)
SKP1 [cytosol]
(Homo sapiens)
Participates
as an input of
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Homo sapiens)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)
as an output of
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)
as a component of
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Homo sapiens)
Inferred To
BTRC:CUL1:SKP1 [cytosol]
(Xenopus tropicalis)
SCF-beta-TRCP [cytosol]
(Rattus norvegicus)
SCF-beta-TRCP [cytosol]
(Sus scrofa)
CUL1:FBXW11:SKP1 [cytosol]
(Bos taurus)
CUL1:FBXW11:SKP1 [cytosol]
(Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol]
(Gallus gallus)
CUL1:FBXW11:SKP1 [cytosol]
(Mus musculus)
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