Reactome | EIF-4E [cytosol]

EIF-4E [cytosol]

Stable Identifier

R-DME-110511

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P48598 eIF4E1

Gene Names

eIF4E1, eIF-4E, Eif4e, CG4035

Chain

chain:1-259

Reference Genes

BioGPS Gene:45525 EIF4E1

CTD Gene:45525 EIF4E1

KEGG:dme:Dmel_CG4035 EIF4E1

Monarch:45525 EIF4E1

NCBI Gene:45525 EIF4E1

UCSC:P48598 EIF4E1

Reference Transcript

Participates

as an output of

Activated DTOR also phosphorylates D4EBP (Drosophila melanogaster)

as a component of

DeIF4E:D4EBP complex [cytosol] (Drosophila melanogaster)

Other forms of this molecule

EIF4E [cytosol]

Cross References

RefSeq

NP_524829.1, NP_729484.1, NP_729482.1, NP_729480.1, NP_729481.1, NP_729485.1, NP_729483.1, NP_001261626.1, NP_001261627.1

ENSEMBL

FBtr0076491, FBpp0076220, FBtr0076493, FBtr0076490, FBtr0076492, FBgn0015218, FBpp0076221, FBpp0076215, FBpp0306017, FBpp0306016, FBtr0333885, FBpp0076218, FBpp0076217, FBtr0076487, FBtr0333884, FBtr0076489, FBpp0076219

PRO

P48598

FlyBase

FBgn0015218

PDB

5T47, 5T48, 4UE9, 4UE8, 5ABU, 4UEA, 5ABV, 4UEB, 4AXG, 4UEC

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9XZ56 Thor	4	Phosphorylated D4EBP [cytosol] (R-DME-110517) THOR [cytosol] (R-DME-110509) phospho-Thor [cytosol] (R-DME-165685) Thor [cytosol] (R-DME-72580)	0.765	6
UniProt:Q9VMA3 CUP			0.757	7
UniProt:P23128	1	DDX6 [cytosol] (R-DME-430032)	0.677	6
UniProt:O61380 O61380			0.573	4
UniProt:Q23972 SMG			0.524	2
UniProt:P21187	1	pAbp [cytosol] (R-DME-156803)	0.499	2
UniProt:Q9VSG1 Q9VSG1			0.462	2

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