Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
eIF4E1 [cytosol]
Stable Identifier
R-DME-72578
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
EIF4E, P48598
Locations in the PathwayBrowser
Expand all
Immune System (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Interferon Signaling (Drosophila melanogaster)
Antiviral mechanism by IFN-stimulated genes (Drosophila melanogaster)
ISG15 antiviral mechanism (Drosophila melanogaster)
Competitive inhibition of translation initiation by ISGylated 4EHP (Drosophila melanogaster)
EIF4F [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
eIF4F:mRNA [cytosol] (Drosophila melanogaster)
EIF4F [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
Metabolism of RNA (Drosophila melanogaster)
Processing of Capped Intron-Containing Pre-mRNA (Drosophila melanogaster)
Transport of Mature Transcript to Cytoplasm (Drosophila melanogaster)
Transport of Mature mRNAs Derived from Intronless Transcripts (Drosophila melanogaster)
Transport of Mature mRNA Derived from an Intronless Transcript (Drosophila melanogaster)
Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
Mature Intronless Transcript Derived mRNA:eIF4E Complex [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
Transport of the SLBP Dependant Mature mRNA (Drosophila melanogaster)
Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
Transport of the SLBP independent Mature mRNA (Drosophila melanogaster)
Release of the SLBP independent Histone mRNA from the NPC (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
Mature SLBP independent Histone mRNA:eIF4E complex [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Translation (Drosophila melanogaster)
Eukaryotic Translation Initiation (Drosophila melanogaster)
Cap-dependent Translation Initiation (Drosophila melanogaster)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Drosophila melanogaster)
Formation of the cap-binding eIF4F complex (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
eIF4F [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
Release of eIF4E from the inactive eIF4E:4E-BP complex (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
eIF4E:4E-BP [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
Translation initiation complex formation (Drosophila melanogaster)
Formation of translation initiation complexes containing mRNA that does not circularize (Drosophila melanogaster)
48S complex [cytosol] (Drosophila melanogaster)
eIF4F [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Drosophila melanogaster)
eIF4F [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
Ribosomal scanning and start codon recognition (Drosophila melanogaster)
Ribosomal scanning (Drosophila melanogaster)
48S complex [cytosol] (Drosophila melanogaster)
eIF4F [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
Start codon recognition (Drosophila melanogaster)
48S complex [cytosol] (Drosophila melanogaster)
eIF4F [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
L13a-mediated translational silencing of Ceruloplasmin expression (Drosophila melanogaster)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Drosophila melanogaster)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Drosophila melanogaster)
eIF4F [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Drosophila melanogaster)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Drosophila melanogaster)
eIF4F [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
MTOR signalling (Drosophila melanogaster)
mTORC1-mediated signalling (Drosophila melanogaster)
Dissociation of phosphorylated 4EBP1 from eIF4E (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
eIF4E:4E-BP1-P [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
Phosphorylation of 4E-BP1 by activated mTORC1 (Drosophila melanogaster)
eIF4E:4E-BP [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
eIF4E:4E-BP1-P [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
eIF4E1 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P48598 eIF4E1
Gene Names
eIF4E1, eIF-4E, Eif4e, CG4035
Chain
chain:1-259
Reference Genes
BioGPS Gene:45525 EIF4E1
CTD Gene:45525 eIF4E1
KEGG:dme:Dmel_CG4035 EIF4E1
Monarch:45525 EIF4E1
NCBI Gene:45525 EIF4E1
UCSC:P48598 EIF4E1
Reference Transcript
RefSeq:NM_168334.1 EIF4E1
RefSeq:NM_168335.2 EIF4E1
RefSeq:NM_168333.2 EIF4E1
RefSeq:NM_080090.3 EIF4E1
RefSeq:NM_001274697.1 EIF4E1
RefSeq:NM_001274698.1 EIF4E1
RefSeq:NM_168338.2 EIF4E1
RefSeq:NM_168337.2 EIF4E1
RefSeq:NM_168336.2 EIF4E1
Participates
as a member of
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
Other forms of this molecule
EIF-4E [cytosol]
Inferred From
EIF4E [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_729480.1
,
NP_001261626.1
,
NP_001261627.1
,
NP_729481.1
,
NP_729482.1
,
NP_729484.1
,
NP_524829.1
,
NP_729485.1
,
NP_729483.1
ENSEMBL
FBpp0306016
,
FBpp0076221
,
FBpp0076220
,
FBpp0306017
,
FBtr0076490
,
FBpp0076215
,
FBtr0076492
,
FBtr0076491
,
FBtr0076493
,
FBgn0015218
,
FBpp0076219
,
FBpp0076218
,
FBtr0333884
,
FBpp0076217
,
FBtr0333885
,
FBtr0076489
,
FBtr0076487
PRO
P48598
FlyBase
FBgn0015218
PDB
5T47
,
5T48
,
4UE9
,
4UEA
,
4UE8
,
4UEB
,
4UEC
,
4AXG
,
5ABU
,
5ABV
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9XZ56 Thor
4
Phosphorylated D4EBP [cytosol]
(R-DME-110517)
THOR [cytosol]
(R-DME-110509)
phospho-Thor [cytosol]
(R-DME-165685)
Thor [cytosol]
(R-DME-72580)
0.765
6
UniProt:Q9VMA3 CUP
0.757
7
UniProt:P23128
1
me31B [cytosol]
(R-DME-430032)
0.677
6
UniProt:O61380 O61380
0.573
4
UniProt:Q23972 SMG
0.524
2
UniProt:P21187 PABP
0.499
2
UniProt:Q9VSG1
1
eIF4E3 [cytosol]
(R-DME-72578-5)
0.462
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text