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EIF4E [cytosol]
Stable Identifier
R-DME-72578
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
P48598
Locations in the PathwayBrowser
Expand all
Immune System (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Interferon Signaling (Drosophila melanogaster)
Antiviral mechanism by IFN-stimulated genes (Drosophila melanogaster)
ISG15 antiviral mechanism (Drosophila melanogaster)
Competitive inhibition of translation initiation by ISGylated 4EHP (Drosophila melanogaster)
EIF4F [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
eIF4F:mRNA [cytosol] (Drosophila melanogaster)
EIF4F [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
Metabolism of RNA (Drosophila melanogaster)
Processing of Capped Intron-Containing Pre-mRNA (Drosophila melanogaster)
Transport of Mature Transcript to Cytoplasm (Drosophila melanogaster)
Transport of Mature mRNAs Derived from Intronless Transcripts (Drosophila melanogaster)
Transport of Mature mRNA Derived from an Intronless Transcript (Drosophila melanogaster)
Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
Mature Intronless Transcript Derived mRNA:eIF4E Complex [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
Transport of the SLBP Dependant Mature mRNA (Drosophila melanogaster)
Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
Transport of the SLBP independent Mature mRNA (Drosophila melanogaster)
Release of the SLBP independent Histone mRNA from the NPC (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
Mature SLBP independent Histone mRNA:eIF4E complex [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Translation (Drosophila melanogaster)
Eukaryotic Translation Initiation (Drosophila melanogaster)
Cap-dependent Translation Initiation (Drosophila melanogaster)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Drosophila melanogaster)
Formation of the cap-binding eIF4F complex (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
eIF4F [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
Release of eIF4E from the inactive eIF4E:4E-BP complex (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
eIF4E:4E-BP [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
Translation initiation complex formation (Drosophila melanogaster)
Formation of translation initiation complexes containing mRNA that does not circularize (Drosophila melanogaster)
48S complex [cytosol] (Drosophila melanogaster)
eIF4F [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Drosophila melanogaster)
eIF4F [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
Ribosomal scanning and start codon recognition (Drosophila melanogaster)
Ribosomal scanning (Drosophila melanogaster)
48S complex [cytosol] (Drosophila melanogaster)
eIF4F [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
Start codon recognition (Drosophila melanogaster)
48S complex [cytosol] (Drosophila melanogaster)
eIF4F [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
L13a-mediated translational silencing of Ceruloplasmin expression (Drosophila melanogaster)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Drosophila melanogaster)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Drosophila melanogaster)
eIF4F [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Drosophila melanogaster)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Drosophila melanogaster)
eIF4F [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
MTOR signalling (Drosophila melanogaster)
mTORC1-mediated signalling (Drosophila melanogaster)
Dissociation of phosphorylated 4EBP1 from eIF4E (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
eIF4E:4E-BP1-P [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
Phosphorylation of 4E-BP1 by activated mTORC1 (Drosophila melanogaster)
eIF4E:4E-BP [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
eIF4E:4E-BP1-P [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P48598 eIF4E1
Gene Names
eIF4E1, eIF-4E, Eif4e, CG4035
Chain
chain:1-259
Reference Genes
BioGPS Gene:45525 eIF4E1
CTD Gene:45525 eIF4E1
KEGG Gene (Drosophila melanogaster):Dmel_CG4035 eIF4E1
Monarch:45525 eIF4E1
NCBI Gene:45525 eIF4E1
UCSC:P48598 eIF4E1
Reference Transcript
RefSeq:NM_168334.1 eIF4E1
RefSeq:NM_080090.3 eIF4E1
RefSeq:NM_168335.2 eIF4E1
RefSeq:NM_168338.2 eIF4E1
RefSeq:NM_168337.2 eIF4E1
RefSeq:NM_001274697.1 eIF4E1
RefSeq:NM_168336.2 eIF4E1
RefSeq:NM_001274698.1 eIF4E1
RefSeq:NM_168333.2 eIF4E1
Other Identifiers
141629_at
1629970_s_at
45525
GO:0000339
GO:0000340
GO:0000932
GO:0003723
GO:0003743
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005845
GO:0006412
GO:0006413
GO:0006417
GO:0016070
GO:0016281
GO:0016604
GO:0023052
GO:0031370
GO:0031594
GO:0036464
GO:0043226
GO:0045182
GO:0071598
GO:0097482
GO:0098794
GO:0099537
GO:0099578
GO:1990124
Participates
as a member of
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
Other forms of this molecule
EIF-4E [cytosol]
Inferred From
EIF4E [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_524829.1
,
NP_729483.1
,
NP_001261627.1
,
NP_729480.1
,
NP_001261626.1
,
NP_729485.1
,
NP_729481.1
,
NP_729482.1
,
NP_729484.1
Flybase
FBgn0015218
PRO
P48598
PDB
5ABU
,
4UE8
,
4UEC
,
5T47
,
5ABV
,
4UE9
,
5T48
,
4AXG
,
4UEB
,
4UEA
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9XZ56 Thor
4
Phosphorylated D4EBP [cytosol]
(R-DME-110517)
THOR [cytosol]
(R-DME-110509)
Thor [cytosol]
(R-DME-72580)
phospho-Thor [cytosol]
(R-DME-165685)
0.765
6
UniProt:Q9VMA3 CUP
0.757
7
UniProt:P23128
1
DDX6 [cytosol]
(R-DME-430032)
0.677
6
UniProt:O61380 O61380
0.573
4
UniProt:Q23972 SMG
0.524
2
UniProt:P21187 PABP
0.499
2
UniProt:Q9VSG1
1
eIF4E3 [cytosol]
(R-DME-72578-5)
0.462
2
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