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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
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Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
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How do I search ?
Details Panel
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Analysis Gene Expression
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Analyse gene expression
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BIRC4 [cytosol]
Stable Identifier
R-CFA-50849
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
XIAP, Q38IV1
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Canis familiaris)
Cell junction organization (Canis familiaris)
Cell-cell junction organization (Canis familiaris)
Adherens junctions interactions (Canis familiaris)
Activation of STAT3 by cadherin engagement (Canis familiaris)
Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination (Canis familiaris)
RAC1,(CDC42) Ubiquitin Ligase [cytosol] (Canis familiaris)
(CDC42 E3 ubiquitin ligases) [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
(RAC1 E3 ubiquitin ligases) [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
Programmed Cell Death (Canis familiaris)
Apoptosis (Canis familiaris)
Intrinsic Pathway for Apoptosis (Canis familiaris)
Apoptotic factor-mediated response (Canis familiaris)
Cytochrome c-mediated apoptotic response (Canis familiaris)
Activation of caspases through apoptosome-mediated cleavage (Canis familiaris)
Cleavage of Procaspase-3 by the apoptosome (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
Cleavage of Procaspase-7 by the apoptosome (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
Formation of apoptosome (Canis familiaris)
Regulation of the apoptosome activity (Canis familiaris)
XIAP binds CASP9 (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
XIAP:apoptosome [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
SMAC, XIAP-regulated apoptotic response (Canis familiaris)
SEPT4 binds XIAP (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
SEPT4 dimer:XIAP [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
SMAC (DIABLO) binds to IAPs (Canis familiaris)
SMAC (DIABLO) binds XIAP (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
DIABLO dimer:XIAP [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
SMAC binds XIAP:Caspase-7 (Canis familiaris)
DIABLO:XIAP:Caspase-7 [cytosol] (Canis familiaris)
XIAP:Caspase-7 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
XIAP:Caspase-7 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes (Canis familiaris)
Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Canis familiaris)
DIABLO dimer:XIAP [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
DIABLO:XIAP:Caspase-7 [cytosol] (Canis familiaris)
XIAP:Caspase-7 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
XIAP binds CASP3 (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
DIABLO:XIAP:Caspase-3 [cytosol] (Canis familiaris)
XIAP:Caspase-3 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
XIAP:Caspase-3 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
XIAP binds CASP7 (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
XIAP:Caspase-7 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
Regulated Necrosis (Canis familiaris)
RIPK1-mediated regulated necrosis (Canis familiaris)
Regulation of necroptotic cell death (Canis familiaris)
BIRC2/3 (cIAP1/2) is autoubiquitinated (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
TNF signaling (Canis familiaris)
Regulation of TNFR1 signaling (Canis familiaris)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Canis familiaris)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
CLIP3 and CYLD bind TNF signaling complex (Canis familiaris)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
K63polyUb-RIPK1 is deubiquitinated (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
LUBAC ubiquitinates RIPK1 at K627 (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
OPTN recruits CYLD to the TNFR1 complex (Canis familiaris)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Canis familiaris)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Canis familiaris)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNFR1-induced NF-kappa-B signaling pathway (Canis familiaris)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
TNFR1-induced proapoptotic signaling (Canis familiaris)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Canis familiaris)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
PTEN Regulation (Canis familiaris)
Regulation of PTEN localization (Canis familiaris)
PTEN undergoes monoubiquitination (Canis familiaris)
XIAP,NEDD4 [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
Regulation of PTEN stability and activity (Canis familiaris)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Canis familiaris)
NEDD4,STUB1,WWP2 and XIAP [cytosol] (Canis familiaris)
BIRC4 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:Q38IV1
Gene Names
BIRC4
Reference Genes
BioGPS Gene:442989 BIRC4
ENSEMBL:ENSCAFG00845025680.1
KEGG:cfa:442989 BIRC4
Monarch:442989 BIRC4
NCBI Gene:442989 BIRC4
UCSC:Q38IV1 BIRC4
Reference Transcript
RefSeq:NM_001284458.1 BIRC4
Other Identifiers
442989
Cfa.4543.1.S1_s_at
Cfa.563.1.S1_at
CfaAffx.28391.1.S1_at
GO:0003824
GO:0004842
GO:0004869
GO:0005634
GO:0005737
GO:0006511
GO:0006915
GO:0006974
GO:0007249
GO:0008270
GO:0010804
GO:0016055
GO:0016740
GO:0019805
GO:0031398
GO:0032480
GO:0032481
GO:0032496
GO:0038066
GO:0042742
GO:0042802
GO:0042981
GO:0043066
GO:0043123
GO:0043124
GO:0046330
GO:0046872
GO:0051402
GO:0060785
GO:0061630
GO:0070427
GO:0070431
GO:0070534
GO:0090263
GO:0097039
GO:0097194
GO:0098542
GO:0098772
GO:0120283
GO:0140096
GO:1902530
Participates
as a candidate of
(RAC1 E3 ubiquitin ligases) [cytosol] (Canis familiaris)
(CDC42 E3 ubiquitin ligases) [cytosol] (Canis familiaris)
XIAP,NEDD4 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
as a member of
NEDD4,STUB1,WWP2 and XIAP [cytosol] (Canis familiaris)
as an input of
SEPT4 binds XIAP (Canis familiaris)
SMAC (DIABLO) binds XIAP (Canis familiaris)
XIAP binds CASP3 (Canis familiaris)
XIAP binds CASP7 (Canis familiaris)
XIAP binds CASP9 (Canis familiaris)
as a component of
SEPT4 dimer:XIAP [cytosol] (Canis familiaris)
XIAP:apoptosome [cytosol] (Canis familiaris)
XIAP:Caspase-7 [cytosol] (Canis familiaris)
DIABLO dimer:XIAP [cytosol] (Canis familiaris)
XIAP:Caspase-3 [cytosol] (Canis familiaris)
This entity regulates
Negatively
Cleavage of Procaspase-7 by the apoptosome
(Canis familiaris)
Cleavage of Procaspase-3 by the apoptosome
(Canis familiaris)
Other forms of this molecule
BIRC4 [nucleoplasm]
BIRC4 [cytosol]
Inferred From
XIAP [cytosol]
(Homo sapiens)
XIAP [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001271387.1
ENSEMBL
ENSCAFG00845025680
,
ENSCAFT00845045351
,
ENSCAFP00845035569
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