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About
What is Reactome ?
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BIRC2,3,4 [cytosol]
Stable Identifier
R-CFA-5357900
Type
Set [CandidateSet]
Species
Canis familiaris
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
TNFR2 non-canonical NF-kB pathway (Canis familiaris)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Canis familiaris)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Canis familiaris)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Canis familiaris)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TRAF2:cIAP1/2 complex binds FN14:TWEAK (Canis familiaris)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TRAF3 binds BAFFR:BAFF (Canis familiaris)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TRAFs bind RANK:RANKL (Canis familiaris)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Canis familiaris)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Canis familiaris)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TRAF3:NIK binds TRAF2:cIAP1/2 (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Canis familiaris)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
Programmed Cell Death (Canis familiaris)
Regulated Necrosis (Canis familiaris)
RIPK1-mediated regulated necrosis (Canis familiaris)
Regulation of necroptotic cell death (Canis familiaris)
BIRC2/3 (cIAP1/2) is autoubiquitinated (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
TNF signaling (Canis familiaris)
Regulation of TNFR1 signaling (Canis familiaris)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Canis familiaris)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
CLIP3 and CYLD bind TNF signaling complex (Canis familiaris)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
K63polyUb-RIPK1 is deubiquitinated (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
LUBAC ubiquitinates RIPK1 at K627 (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
OPTN recruits CYLD to the TNFR1 complex (Canis familiaris)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Canis familiaris)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Canis familiaris)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNFR1-induced NF-kappa-B signaling pathway (Canis familiaris)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
TNFR1-induced proapoptotic signaling (Canis familiaris)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Canis familiaris)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
Participants
members
BIRC2 [cytosol]
(Canis familiaris)
BIRC3 [cytosol]
(Canis familiaris)
candidates
BIRC4 [cytosol]
(Canis familiaris)
Participates
as a component of
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
as an output of
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
as an input of
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Canis familiaris)
BIRC2/3 (cIAP1/2) is autoubiquitinated (Canis familiaris)
Inferred From
cIAP1,2 [cytosol]
(Homo sapiens)
BIRC2,3,4 [cytosol]
(Homo sapiens)
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