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Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane]
Stable Identifier
R-CFA-198299
Type
Complex
Species
Canis familiaris
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
PI3K/AKT activation (Canis familiaris)
Active IRS recruits PI3K to the plasma membrane and activates it (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Canis familiaris)
PI3K produces PIP3 and other phosphatidyl inositides (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
mature beta-NGF homodimer [extracellular region]
(Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol]
(Canis familiaris)
x 2
phospho-p-5Y-NTRK1 [plasma membrane]
(Canis familiaris)
Participates
as an input of
Active IRS recruits PI3K to the plasma membrane and activates it (Canis familiaris)
as a component of
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Canis familiaris)
Inferred From
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane]
(Homo sapiens)
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