Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
mature beta-NGF homodimer [extracellular region]
Stable Identifier
R-CFA-187031
Type
Complex
Species
Canis familiaris
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
p75 NTR receptor-mediated signalling (Canis familiaris)
Cell death signalling via NRAGE, NRIF and NADE (Canis familiaris)
NADE modulates death signalling (Canis familiaris)
14-3-3epsilon attentuates NADE-related apoptosis (Canis familiaris)
NGF ligand:p75NTR:NADE:14-3-3epsilon [plasma membrane] (Canis familiaris)
NGF:p75NTR:NADE [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF:p75NTR:NADE [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
p75NTR binds to NADE (Canis familiaris)
NGF:p75NTR:NADE [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
p75NTR:NADE promotes caspase2/3 activation (Canis familiaris)
NGF:p75NTR:NADE [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NRIF signals cell death from the nucleus (Canis familiaris)
TRAF6 binds to p75NTR:NRIF (Canis familiaris)
NGF ligand:p75NTR:NRIF [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:NRIF [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Canis familiaris)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:NRIF [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NFG and proNGF binds to p75NTR (Canis familiaris)
NGF homodimer binds to p75NTR (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
p75NTR regulates axonogenesis (Canis familiaris)
Axonal growth stimulation (Canis familiaris)
NGF binding to p75NTR inactivates RHOA (Canis familiaris)
RHOA:GDP:ARHGDIA:NGFR:NGF [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
p75NTR signals via NF-kB (Canis familiaris)
NF-kB is activated and signals survival (Canis familiaris)
IKKbeta is activated (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
p75NTR recruits signalling complexes (Canis familiaris)
IKK-beta is recruited (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
IRAK interacts with TRAF6 (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
MYD88 dissociates (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
TRAF6 is auto-ubiquitinated (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
p62 is recruited and forms a complex with TRAF6 (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
p62 recruits an atypical PKC (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
p75NTR interacts with RIP2 (Canis familiaris)
NGF:p75NTR:RIP2 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by NTRKs (Canis familiaris)
Expression and Processing of Neurotrophins (Canis familiaris)
NGF processing (Canis familiaris)
Pro-beta-NGF and mature beta-NGF are secreted (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
Activation of TRKA receptors (Canis familiaris)
TRKA activation by NGF (Canis familiaris)
Activated TrkA receptor internalizes to endosomes (Canis familiaris)
Activated TrkA receptor complex [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
The bound receptor dimerizes (Canis familiaris)
beta-NGF dimer:TrkA receptor [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
beta-NGF dimer:TrkA receptor dimer [plasma membrane] (Canis familiaris)
beta-NGF dimer:TrkA receptor [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
beta-NGF dimer binds to TrkA receptor (Canis familiaris)
beta-NGF dimer:TrkA receptor [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
PI3K/AKT activation (Canis familiaris)
Active IRS recruits PI3K to the plasma membrane and activates it (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
Retrograde neurotrophin signalling (Canis familiaris)
Axonal transport of NGF:Trk complexes (Canis familiaris)
Activated TrkA receptor complex:Clathrin-coated vesicle:Endophilin [plasma membrane] (Canis familiaris)
Activated TrkA receptor complex [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
Signalling to ERKs (Canis familiaris)
Prolonged ERK activation events (Canis familiaris)
ARMS-mediated activation (Canis familiaris)
ARMS is phosphorylated by active TrkA receptor (Canis familiaris)
Active TrkA receptor:ARMS:Crk complex [plasma membrane] (Canis familiaris)
Activated TrkA receptor complex [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Canis familiaris)
Activated TrkA receptor complex [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
C3G stimulates nucleotide exchange on Rap1 (Canis familiaris)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Canis familiaris)
Activated TrkA receptor complex [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
Crk's SH3 domain engages C3G (Canis familiaris)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Canis familiaris)
Activated TrkA receptor complex [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
NGF [extracellular region]
(Canis familiaris)
Participates
as an input of
NGF binding to p75NTR inactivates RHOA (Canis familiaris)
NGF homodimer binds to p75NTR (Canis familiaris)
beta-NGF dimer binds to TrkA receptor (Canis familiaris)
as a component of
RHOA:GDP:ARHGDIA:NGFR:NGF [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
beta-NGF dimer:TrkA receptor [plasma membrane] (Canis familiaris)
Activated TrkA receptor complex [plasma membrane] (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Canis familiaris)
as an output of
Pro-beta-NGF and mature beta-NGF are secreted (Canis familiaris)
Inferred From
mature beta-NGF homodimer [extracellular region]
(Homo sapiens)
beta-NGF homodimer [extracellular region]
(Homo sapiens)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text