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Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane]
Stable Identifier
R-HSA-198299
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
PI3K/AKT activation (Homo sapiens)
Active IRS recruits PI3K to the plasma membrane and activates it (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Homo sapiens)
PI3K produces PIP3 and other phosphatidyl inositides (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Homo sapiens)
TRKA phosphorylates IRS (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Homo sapiens)
Participants
components
beta-NGF homodimer [extracellular region]
(Homo sapiens)
x 2
p-5Y-NTRK1 [plasma membrane]
(Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol]
(Homo sapiens)
Participates
as an output of
TRKA phosphorylates IRS (Homo sapiens)
as a component of
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
as an input of
Active IRS recruits PI3K to the plasma membrane and activates it (Homo sapiens)
Inferred To
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane]
(Bos taurus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane]
(Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane]
(Gallus gallus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane]
(Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane]
(Rattus norvegicus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane]
(Sus scrofa)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane]
(Xenopus tropicalis)
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