Reactome | MAGOHB [nucleoplasm]

MAGOHB [nucleoplasm]

Stable Identifier

R-CFA-156658

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

MAGOH, A0A8I3PR32

Locations in the PathwayBrowser

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Metabolism of RNA (Canis familiaris)

- Nonsense-Mediated Decay (NMD) (Canis familiaris)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Canis familiaris)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Canis familiaris)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Canis familiaris)
        
        Magoh-Y14 complex [cytosol] (Canis familiaris)
        
        MAGOHB [nucleoplasm] (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Canis familiaris)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Canis familiaris)
        
        Magoh-Y14 complex [cytosol] (Canis familiaris)
        
        MAGOHB [nucleoplasm] (Canis familiaris)
    - SMG6 hydrolyzes mRNA with premature termination codon (Canis familiaris)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Canis familiaris)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Canis familiaris)
        
        Magoh-Y14 complex [cytosol] (Canis familiaris)
        
        MAGOHB [nucleoplasm] (Canis familiaris)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Canis familiaris)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Canis familiaris)
        
        Magoh-Y14 complex [cytosol] (Canis familiaris)
        
        MAGOHB [nucleoplasm] (Canis familiaris)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Canis familiaris)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Canis familiaris)
        
        Magoh-Y14 complex [cytosol] (Canis familiaris)
        
        MAGOHB [nucleoplasm] (Canis familiaris)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Canis familiaris)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Canis familiaris)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Canis familiaris)
        
        Magoh-Y14 complex [cytosol] (Canis familiaris)
        
        MAGOHB [nucleoplasm] (Canis familiaris)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Canis familiaris)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Canis familiaris)
        
        Magoh-Y14 complex [cytosol] (Canis familiaris)
        
        MAGOHB [nucleoplasm] (Canis familiaris)
- Processing of Capped Intron-Containing Pre-mRNA (Canis familiaris)
  - Transport of Mature Transcript to Cytoplasm (Canis familiaris)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Canis familiaris)
      - Transport of the export-competent mRNP complex through the NPC (Canis familiaris)
        
        NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] (Canis familiaris)
        
        EJC [nucleoplasm] (Canis familiaris)
        
        Core EJC [nucleoplasm] (Canis familiaris)
        
        Magoh-Y14 complex [nucleoplasm] (Canis familiaris)
        
        MAGOHB [nucleoplasm] (Canis familiaris)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Canis familiaris)
        
        EJC [cytosol] (Canis familiaris)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Canis familiaris)
        
        Magoh-Y14 complex [cytosol] (Canis familiaris)
        
        MAGOHB [nucleoplasm] (Canis familiaris)
  - mRNA 3'-end processing (Canis familiaris)
    - TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Canis familiaris)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Canis familiaris)
        
        EJC [nucleoplasm] (Canis familiaris)
        
        Core EJC [nucleoplasm] (Canis familiaris)
        
        Magoh-Y14 complex [nucleoplasm] (Canis familiaris)
        
        MAGOHB [nucleoplasm] (Canis familiaris)
      - Spliced mRNP [nucleoplasm] (Canis familiaris)
        
        EJC [nucleoplasm] (Canis familiaris)
        
        Core EJC [nucleoplasm] (Canis familiaris)
        
        Magoh-Y14 complex [nucleoplasm] (Canis familiaris)
        
        MAGOHB [nucleoplasm] (Canis familiaris)
  - mRNA Splicing (Canis familiaris)
    - mRNA Splicing - Major Pathway (Canis familiaris)
      - Formation of the Spliceosomal C complex containing intron lariat (Canis familiaris)
        
        Spliceosomal B* complex [nucleoplasm] (Canis familiaris)
        
        Core EJC [nucleoplasm] (Canis familiaris)
        
        Magoh-Y14 complex [nucleoplasm] (Canis familiaris)
        
        MAGOHB [nucleoplasm] (Canis familiaris)
        
        Spliceosomal C complex [nucleoplasm] (Canis familiaris)
        
        Core EJC [nucleoplasm] (Canis familiaris)
        
        Magoh-Y14 complex [nucleoplasm] (Canis familiaris)
        
        MAGOHB [nucleoplasm] (Canis familiaris)
      - Formation of the Spliceosomal C* complex (Canis familiaris)
        
        Spliceosomal C complex [nucleoplasm] (Canis familiaris)
        
        Core EJC [nucleoplasm] (Canis familiaris)
        
        Magoh-Y14 complex [nucleoplasm] (Canis familiaris)
        
        MAGOHB [nucleoplasm] (Canis familiaris)
        
        Spliceosomal C* complex [nucleoplasm] (Canis familiaris)
        
        Core EJC [nucleoplasm] (Canis familiaris)
        
        Magoh-Y14 complex [nucleoplasm] (Canis familiaris)
        
        MAGOHB [nucleoplasm] (Canis familiaris)
      - Formation of the Spliceosomal P complex and exon ligation (Canis familiaris)
        
        Spliceosomal C* complex [nucleoplasm] (Canis familiaris)
        
        Core EJC [nucleoplasm] (Canis familiaris)
        
        Magoh-Y14 complex [nucleoplasm] (Canis familiaris)
        
        MAGOHB [nucleoplasm] (Canis familiaris)
        
        Spliceosomal P complex [nucleoplasm] (Canis familiaris)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Canis familiaris)
        
        EJC [nucleoplasm] (Canis familiaris)
        
        Core EJC [nucleoplasm] (Canis familiaris)
        
        Magoh-Y14 complex [nucleoplasm] (Canis familiaris)
        
        MAGOHB [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PR32

Gene Names

MAGOHB

Reference Genes

BioGPS Gene:477695 MAGOHB

ENSEMBL:ENSCAFG00845025519.1

KEGG:cfa:477695 MAGOHB

Monarch:477695 MAGOHB

NCBI Gene:477695 MAGOHB

UCSC:A0A8I3PR32 MAGOHB

Reference Transcript

Other Identifiers

477695

Cfa.10068.1.A1_at

CfaAffx.15627.1.S1_s_at

GO:0000184

GO:0000398

GO:0005634

GO:0005681

GO:0008380

GO:0016071

GO:0035145

GO:0051028

GO:0071013

GO:1990501

Participates

as a component of

Inferred From

MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)

MAGOH [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_038294932.1, XP_038432724.1, XP_534889.1

ENSEMBL

ENSCAFP00845035311, ENSCAFT00845045049, ENSCAFG00845025519

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