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LUBAC [cytosol]
Stable Identifier
R-BTA-5357865
Type
Complex
Species
Bos taurus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Bos taurus)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
LUBAC ubiquitinates RIPK1 at K627 (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
OPTN recruits CYLD to the TNFR1 complex (Bos taurus)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNFR1-induced NF-kappa-B signaling pathway (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
TNFR1-induced proapoptotic signaling (Bos taurus)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Bos taurus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
C20orf18 [cytosol]
(Bos taurus)
Ghost homologue of SHARPIN [cytosol]
(Bos taurus)
RNF31 [cytosol]
(Bos taurus)
Participates
as a component of
CFLAR:LUBAC:Ub:UBE2D3 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
Inferred From
LUBAC [cytosol]
(Homo sapiens)
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