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RBCK1 [cytosol]
Stable Identifier
R-BTA-976018
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
RBCK1, Q1JPC8
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
Polyubiquitination of substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
Release of E3 from polyubiquitinated substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Bos taurus)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
LUBAC binds CFLAR (Bos taurus)
CFLAR:LUBAC:Ub:UBE2D3 [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
LUBAC binds OTULIN (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
LUBAC:OTULIN [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
LUBAC ubiquitinates CFLAR at K351, K353 (Bos taurus)
CFLAR:LUBAC:Ub:UBE2D3 [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
LUBAC ubiquitinates RIPK1 at K627 (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
OPTN recruits CYLD to the TNFR1 complex (Bos taurus)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
SPATA2 links CYLD to LUBAC (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNFR1-induced NF-kappa-B signaling pathway (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNFR1-induced proapoptotic signaling (Bos taurus)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Bos taurus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q1JPC8
Gene Names
RBCK1
Reference Genes
BioGPS Gene:504400 RBCK1
ENSEMBL:ENSBTAG00000017002.6
KEGG:bta:504400 RBCK1
Monarch:504400 RBCK1
NCBI Gene:504400 RBCK1
UCSC:Q1JPC8 RBCK1
Reference Transcript
RefSeq:NM_001075161.1 RBCK1
Participates
as a component of
LUBAC [cytosol] (Bos taurus)
as a member of
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
Inferred From
RBCK1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001068629.1
VGNC
33776
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