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RNF31 [cytosol]
Stable Identifier
R-BTA-5212660
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
RNF31, E1BMK3
Locations in the PathwayBrowser
Expand all
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Bos taurus)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
LUBAC ubiquitinates RIPK1 at K627 (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
OPTN recruits CYLD to the TNFR1 complex (Bos taurus)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNFR1-induced NF-kappa-B signaling pathway (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
TNFR1-induced proapoptotic signaling (Bos taurus)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Bos taurus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RNF31 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:E1BMK3
Gene Names
RNF31
Reference Genes
ENSEMBL:ENSBTAG00000005815.7
UCSC:E1BMK3 RNF31
Other Identifiers
509856
GO:0000209
GO:0002376
GO:0003824
GO:0004842
GO:0005829
GO:0008270
GO:0009898
GO:0016567
GO:0016740
GO:0023035
GO:0031625
GO:0035631
GO:0042742
GO:0042802
GO:0043123
GO:0043130
GO:0046872
GO:0050852
GO:0060546
GO:0061630
GO:0071797
GO:0097039
GO:0098542
GO:0140096
GO:1904417
Participates
as a component of
LUBAC [cytosol] (Bos taurus)
Inferred From
RNF31 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSBTAP00000053642
,
ENSBTAT00000061147
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