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C3 [extracellular region]
Stable Identifier
R-BTA-166821
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
extracellular region
Synonyms
C3 beta chain, Q2UVX4
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Complement cascade (Bos taurus)
Activation of C3 and C5 (Bos taurus)
Activation of C5 (Bos taurus)
C5 convertases [plasma membrane] (Bos taurus)
C3b:Bb:C3b:Properdin [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
C4b:C2a:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Cleavage of C3 by C3 convertases (Bos taurus)
C3 convertases [plasma membrane] (Bos taurus)
C3(H2O):Bb [extracellular region] (Bos taurus)
C3(H2O) [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
C4b:C2a:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Cell surface:C3b:Bb [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Complement factor 3 [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Formation of classic pathway C5 convertase (Bos taurus)
C4b:C2a:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Initial triggering of complement (Bos taurus)
Alternative complement activation (Bos taurus)
C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Bos taurus)
C3(H2O):Bb [extracellular region] (Bos taurus)
C3(H2O) [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Complement factor 3 [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
C3b binds to cell surface (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Factor B binds to C3(H2O) (Bos taurus)
C3(H2O) [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
C3(H2O):CFB [extracellular region] (Bos taurus)
C3(H2O) [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Factor B binds to surface-associated C3b (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Cell surface:C3b:CFB [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Factor D cleaves C3(H2O)-bound Factor B (Bos taurus)
C3(H2O):Bb [extracellular region] (Bos taurus)
C3(H2O) [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
C3(H2O):CFB [extracellular region] (Bos taurus)
C3(H2O) [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Factor D cleaves C3b-bound Factor B (Bos taurus)
Cell surface:C3b:Bb [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Cell surface:C3b:CFB [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Formation of alternative pathway C5 convertase (Bos taurus)
C3b:Bb:C3b:Properdin [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Complement factor 3 [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Properdin stabilizes C3b:Bb bound to cell surfaces (Bos taurus)
Cell surface:C3b:Bb [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Spontaneous hydrolysis of C3 thioester (Bos taurus)
C3(H2O) [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Complement factor 3 [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Regulation of Complement cascade (Bos taurus)
C3 convertases spontaneously dissociate (Bos taurus)
C3 convertases [plasma membrane] (Bos taurus)
C3(H2O):Bb [extracellular region] (Bos taurus)
C3(H2O) [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
C4b:C2a:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Cell surface:C3b:Bb [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
C3(H2O) [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
CD46 binds C3b (Bos taurus)
CD46:Cell surface:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
CD55 (DAF) binds C3bBb, C4bC2a (Bos taurus)
C4bC2a, C3bBb [plasma membrane] (Bos taurus)
Cell surface:C3b:Bb [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
CD55:C3 convertase complexes [plasma membrane] (Bos taurus)
CD55:C3bBb [plasma membrane] (Bos taurus)
Cell surface:C3b:Bb [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Bos taurus)
CD55:C3 convertase complexes [plasma membrane] (Bos taurus)
CD55:C3bBb [plasma membrane] (Bos taurus)
Cell surface:C3b:Bb [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
CD55:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
CFHR dimers bind C3b (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Cell surface:C3b:CFHR dimers [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Complement factor I binds to MCP, CR1:C4b, C3b (Bos taurus)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Bos taurus)
CD46:Cell surface:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Bos taurus)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Bos taurus)
CD46:Cell surface:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Complement factor I binds to extracellular Factor H:C3b (Bos taurus)
CFH:C3b [extracellular region] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
CFI:CFH:C3b [extracellular region] (Bos taurus)
CFH:C3b [extracellular region] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Complement factor I binds to membrane-associated Factor H:C3b (Bos taurus)
CFI:CFH,FHR3:C3b [plasma membrane] (Bos taurus)
Cell surface:FH,FHR3:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Cell surface:FH,FHR3:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Factor H binds to C3b (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
CFH:C3b [extracellular region] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Factor H binds to C3bBb (Bos taurus)
Cell surface:C3b:Bb [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Cell surface:CFH, CFHR3:C3bBb [plasma membrane] (Bos taurus)
Cell surface:C3b:Bb [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Factor H binds to membrane-associated C3b (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Cell surface:FH,FHR3:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Factor H displaces Bb (Bos taurus)
Cell surface:CFH, CFHR3:C3bBb [plasma membrane] (Bos taurus)
Cell surface:C3b:Bb [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Cell surface:FH,FHR3:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Factor I inactivates Factor H-boundC3b (Bos taurus)
CFI:CFH,FHR3:C3b [plasma membrane] (Bos taurus)
Cell surface:FH,FHR3:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Factor I inactivates MCP/CR1-bound C4b/C3b (Bos taurus)
CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Bos taurus)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Bos taurus)
CD46:Cell surface:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
Factor I inactivates plasma Factor H-bound C3b (Bos taurus)
CFI:CFH:C3b [extracellular region] (Bos taurus)
CFH:C3b [extracellular region] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
iC3b [extracellular region] (Bos taurus)
C3 [extracellular region] (Bos taurus)
External Reference Information
External Reference
UniProt:Q2UVX4
Gene Names
C3
Reference Genes
BioGPS Gene:280677 C3
ENSEMBL:ENSBTAG00000017280
KEGG:bta:280677 C3
Monarch:280677 C3
NCBI Gene:280677 C3
UCSC:Q2UVX4 C3
Reference Transcript
RefSeq:NM_001040469.2 C3
RefSeq:XM_010806886.2 C3
Other Identifiers
280677
GO:0001798
GO:0001970
GO:0002376
GO:0002430
GO:0004866
GO:0005576
GO:0005615
GO:0006954
GO:0006956
GO:0006957
GO:0006958
GO:0009617
GO:0009986
GO:0010575
GO:0010828
GO:0010866
GO:0010884
GO:0016322
GO:0022414
GO:0031715
GO:0032991
GO:0034330
GO:0035846
GO:0042113
GO:0045745
GO:0045766
GO:0048018
GO:0048260
GO:0048856
GO:0050766
GO:0060100
GO:0097242
GO:0097278
GO:0098542
GO:0098772
GO:0150062
GO:0150064
GO:2000427
Participates
as a component of
iC3b [extracellular region] (Bos taurus)
Complement factor 3 [extracellular region] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3(H2O) [extracellular region] (Bos taurus)
Other forms of this molecule
C3 [extracellular region]
C3 [azurophil granule lumen]
C3 [azurophil granule lumen]
C3 [secretory granule lumen]
C3 [secretory granule lumen]
phospho-C3 [endoplasmic reticulum lumen]
C3 [endoplasmic reticulum lumen]
C3 [extracellular region]
C3 [extracellular region]
C3 [extracellular region]
C3 [plasma membrane]
C3 [plasma membrane]
C3 [extracellular region]
C3 [plasma membrane]
C3 [plasma membrane]
C3 [plasma membrane]
C3 [extracellular region]
C3 [extracellular region]
C3 [extracellular region]
C3 [extracellular region]
Inferred From
C3 beta chain [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_001035559.2
,
XP_010805188.1
ENSEMBL
ENSBTAG00000017280
,
ENSBTAT00000022979
,
ENSBTAP00000022979
VGNC
26638
PDB
8CEM
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