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C3b [extracellular region]
Stable Identifier
R-BTA-166832
Type
Complex
Species
Bos taurus
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Complement cascade (Bos taurus)
Activation of C3 and C5 (Bos taurus)
Activation of C5 (Bos taurus)
C5 convertases [plasma membrane] (Bos taurus)
C3b:Bb:C3b:Properdin [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C4b:C2a:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Cleavage of C3 by C3 convertases (Bos taurus)
C3 convertases [plasma membrane] (Bos taurus)
C4b:C2a:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Cell surface:C3b:Bb [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Formation of classic pathway C5 convertase (Bos taurus)
C4b:C2a:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Initial triggering of complement (Bos taurus)
Alternative complement activation (Bos taurus)
C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3b binds to cell surface (Bos taurus)
C3b [extracellular region] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Factor B binds to surface-associated C3b (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Cell surface:C3b:CFB [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Factor D cleaves C3b-bound Factor B (Bos taurus)
Cell surface:C3b:Bb [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Cell surface:C3b:CFB [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Formation of alternative pathway C5 convertase (Bos taurus)
C3b:Bb:C3b:Properdin [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Properdin stabilizes C3b:Bb bound to cell surfaces (Bos taurus)
Cell surface:C3b:Bb [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Regulation of Complement cascade (Bos taurus)
C3 convertases spontaneously dissociate (Bos taurus)
C3 convertases [plasma membrane] (Bos taurus)
C4b:C2a:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Cell surface:C3b:Bb [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
C3b [extracellular region] (Bos taurus)
CD46 binds C3b (Bos taurus)
CD46:Cell surface:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
CD55 (DAF) binds C3bBb, C4bC2a (Bos taurus)
C4bC2a, C3bBb [plasma membrane] (Bos taurus)
Cell surface:C3b:Bb [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
CD55:C3 convertase complexes [plasma membrane] (Bos taurus)
CD55:C3bBb [plasma membrane] (Bos taurus)
Cell surface:C3b:Bb [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Bos taurus)
CD55:C3 convertase complexes [plasma membrane] (Bos taurus)
CD55:C3bBb [plasma membrane] (Bos taurus)
Cell surface:C3b:Bb [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
CD55:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
CFHR dimers bind C3b (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Cell surface:C3b:CFHR dimers [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Complement factor I binds to MCP, CR1:C4b, C3b (Bos taurus)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Bos taurus)
CD46:Cell surface:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Bos taurus)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Bos taurus)
CD46:Cell surface:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Complement factor I binds to extracellular Factor H:C3b (Bos taurus)
CFH:C3b [extracellular region] (Bos taurus)
C3b [extracellular region] (Bos taurus)
CFI:CFH:C3b [extracellular region] (Bos taurus)
CFH:C3b [extracellular region] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Complement factor I binds to membrane-associated Factor H:C3b (Bos taurus)
CFI:CFH,FHR3:C3b [plasma membrane] (Bos taurus)
Cell surface:FH,FHR3:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Cell surface:FH,FHR3:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Factor H binds to C3b (Bos taurus)
C3b [extracellular region] (Bos taurus)
CFH:C3b [extracellular region] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Factor H binds to C3bBb (Bos taurus)
Cell surface:C3b:Bb [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Cell surface:CFH, CFHR3:C3bBb [plasma membrane] (Bos taurus)
Cell surface:C3b:Bb [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Factor H binds to membrane-associated C3b (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Cell surface:FH,FHR3:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Factor H displaces Bb (Bos taurus)
Cell surface:CFH, CFHR3:C3bBb [plasma membrane] (Bos taurus)
Cell surface:C3b:Bb [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Cell surface:FH,FHR3:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Factor I inactivates Factor H-boundC3b (Bos taurus)
CFI:CFH,FHR3:C3b [plasma membrane] (Bos taurus)
Cell surface:FH,FHR3:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Factor I inactivates MCP/CR1-bound C4b/C3b (Bos taurus)
CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Bos taurus)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Bos taurus)
CD46:Cell surface:C3b [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
C3b [extracellular region] (Bos taurus)
Factor I inactivates plasma Factor H-bound C3b (Bos taurus)
CFI:CFH:C3b [extracellular region] (Bos taurus)
CFH:C3b [extracellular region] (Bos taurus)
C3b [extracellular region] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
C3 [extracellular region]
(Bos taurus)
C3 [extracellular region]
(Bos taurus)
Participates
as an output of
C3 convertases spontaneously dissociate (Bos taurus)
Cleavage of C3 by C3 convertases (Bos taurus)
C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Bos taurus)
as a component of
CD55:C3b [plasma membrane] (Bos taurus)
CFH:C3b [extracellular region] (Bos taurus)
C3b:Bb:C3b:Properdin [plasma membrane] (Bos taurus)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Bos taurus)
Cell surface:C3b:Bb [plasma membrane] (Bos taurus)
Cell surface:C3b [plasma membrane] (Bos taurus)
as an input of
Factor H binds to C3b (Bos taurus)
C3b binds to cell surface (Bos taurus)
Inferred From
C3b [extracellular region]
(Homo sapiens)
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