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F2 [extracellular region]
Stable Identifier
R-BTA-140589
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
extracellular region
Synonyms
F2(364-622), A0A452DI66
Locations in the PathwayBrowser
Expand all
Hemostasis (Bos taurus)
Coagulation pathway (Bos taurus)
Amplification and propagation of coagulation cascade (Bos taurus)
factor V -> factor Va + factor V activation peptide (thrombin catalyst) (Bos taurus)
Extracellular thrombin inactivating complexes [extracellular region] (Bos taurus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Bos taurus)
Extracellular thrombin inactivating complexes [extracellular region] (Bos taurus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
Factor IIa inhibitors:IIa [extracellular region] (Bos taurus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Bos taurus)
Extracellular thrombin inactivating complexes [extracellular region] (Bos taurus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
Factor IIa inhibitors:IIa [extracellular region] (Bos taurus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
Fibrin formation (Bos taurus)
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Bos taurus)
Extracellular thrombin inactivating complexes [extracellular region] (Bos taurus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
Factor IIa inhibitors:IIa [extracellular region] (Bos taurus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
Initiation of coagulation cascade (Bos taurus)
factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst) (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
factor Va intermediate -> factor Va (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
Regulation of clotting cascade (Bos taurus)
Factor IIa inhibitors (compounds) binds IIa (Bos taurus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
Factor IIa inhibitors (peptide) bind IIa (Bos taurus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
thrombin:cleaved SERPINC1:HSPGs-> thrombin:cleaved SERPINC1 + HSPGs (Bos taurus)
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
Thrombin signalling through proteinase activated receptors (PARs) (Bos taurus)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Complement cascade (Bos taurus)
Regulation of Complement cascade (Bos taurus)
Thrombin, ELANE cleave C5 (Bos taurus)
Activated thrombin, (ELANE) [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (q) signalling events (Bos taurus)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Bos taurus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
The Ligand:GPCR:Gq complex dissociates (Bos taurus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
GPCR ligand binding (Bos taurus)
Class A/1 (Rhodopsin-like receptors) (Bos taurus)
Peptide ligand-binding receptors (Bos taurus)
Proteinase-activated receptors can bind thrombin (Bos taurus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
F2 [extracellular region] (Bos taurus)
External Reference Information
External Reference
UniProt:A0A452DI66
Gene Names
F2
Reference Genes
ENSEMBL:ENSBTAG00000007148.6
UCSC:A0A452DI66 F2
Other Identifiers
280685
Bt.470.1.S1_at
GO:0001530
GO:0002376
GO:0004175
GO:0004252
GO:0005102
GO:0005509
GO:0005576
GO:0005615
GO:0006508
GO:0006953
GO:0006954
GO:0007166
GO:0007186
GO:0007596
GO:0007599
GO:0008201
GO:0008233
GO:0008236
GO:0008284
GO:0008289
GO:0008360
GO:0009611
GO:0009897
GO:0010468
GO:0016787
GO:0030168
GO:0030194
GO:0030195
GO:0030307
GO:0032024
GO:0032967
GO:0042730
GO:0045861
GO:0048018
GO:0048712
GO:0050878
GO:0051281
GO:0051480
GO:0051604
GO:0051838
GO:0051897
GO:0061844
GO:0070053
GO:0070493
GO:0070945
GO:0072378
GO:0098542
GO:0098772
GO:1900016
GO:1900182
GO:1900738
GO:1990806
GO:2000379
Participates
as a component of
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Other forms of this molecule
F2 [Golgi lumen]
F2 [Golgi lumen]
F2 [Golgi lumen]
F2 [endoplasmic reticulum lumen]
F2 [endoplasmic reticulum lumen]
F2 [plasma membrane]
F2 [plasma membrane]
F2 [extracellular region]
F2 [extracellular region]
F2 [extracellular region]
Inferred From
F2(364-622) [extracellular region]
(Homo sapiens)
Cross References
ENSEMBL
ENSBTAP00000009406
,
ENSBTAT00000009406
,
ENSBTAG00000007148
VGNC
28682
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