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pazopanib [cytosol]
Stable Identifier
R-ALL-9616920
Type
ChemicalDrug
Compartment
cytosol
Synonyms
GW 78603, 5-({4-((2,3-dimethyl-2H-indazol-6-yl)(methyl)amino)pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide, pazopanibum, GW786034
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Sus scrofa
Expand all
Programmed Cell Death (Bos taurus)
Regulated Necrosis (Bos taurus)
RIPK1-mediated regulated necrosis (Bos taurus)
RIPK1 is phosphorylated (Bos taurus)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Bos taurus)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
RIPK3 is phosphorylated (Bos taurus)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Bos taurus)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
Regulation of necroptotic cell death (Bos taurus)
Small molecule inhibitor binds RIPK1, RIPK3 (Bos taurus)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Bos taurus)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by PDGF (Bos taurus)
Autophosphorylation of PDGF alpha receptors (Bos taurus)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Bos taurus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
PDGFRs bind type I TKI (Bos taurus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Bos taurus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
Signal Transduction (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by PDGF (Caenorhabditis elegans)
Autophosphorylation of PDGF alpha receptors (Caenorhabditis elegans)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Caenorhabditis elegans)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
PDGFRs bind type I TKI (Caenorhabditis elegans)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Caenorhabditis elegans)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
Programmed Cell Death (Canis familiaris)
Regulated Necrosis (Canis familiaris)
RIPK1-mediated regulated necrosis (Canis familiaris)
RIPK1 is phosphorylated (Canis familiaris)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Canis familiaris)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
RIPK3 is phosphorylated (Canis familiaris)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Canis familiaris)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
Regulation of necroptotic cell death (Canis familiaris)
Small molecule inhibitor binds RIPK1, RIPK3 (Canis familiaris)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Canis familiaris)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by PDGF (Canis familiaris)
Autophosphorylation of PDGF alpha receptors (Canis familiaris)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Canis familiaris)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
PDGFRs bind type I TKI (Canis familiaris)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Canis familiaris)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
Signal Transduction (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by PDGF (Danio rerio)
Autophosphorylation of PDGF alpha receptors (Danio rerio)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Danio rerio)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
PDGFRs bind type I TKI (Danio rerio)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Danio rerio)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
Programmed Cell Death (Dictyostelium discoideum)
Regulated Necrosis (Dictyostelium discoideum)
RIPK1-mediated regulated necrosis (Dictyostelium discoideum)
RIPK1 is phosphorylated (Dictyostelium discoideum)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Dictyostelium discoideum)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
RIPK3 is phosphorylated (Dictyostelium discoideum)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Dictyostelium discoideum)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
Regulation of necroptotic cell death (Dictyostelium discoideum)
Small molecule inhibitor binds RIPK1, RIPK3 (Dictyostelium discoideum)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Dictyostelium discoideum)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
Signal Transduction (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by PDGF (Drosophila melanogaster)
Autophosphorylation of PDGF alpha receptors (Drosophila melanogaster)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Drosophila melanogaster)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
PDGFRs bind type I TKI (Drosophila melanogaster)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Drosophila melanogaster)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by PDGF (Gallus gallus)
Autophosphorylation of PDGF alpha receptors (Gallus gallus)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Gallus gallus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
PDGFRs bind type I TKI (Gallus gallus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Gallus gallus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR2 in disease (Homo sapiens)
FGFR2 mutant receptor activation (Homo sapiens)
Activated point mutants of FGFR2 (Homo sapiens)
Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors (Homo sapiens)
Tyrosine kinase inhibitors of FGFR2 mutants [cytosol]
pazopanib [cytosol]
FGFR2 point mutant dimers:TKIs [plasma membrane] (Homo sapiens)
Tyrosine kinase inhibitors of FGFR2 mutants [cytosol]
pazopanib [cytosol]
Signaling by FGFR2 amplification mutants (Homo sapiens)
Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants (Homo sapiens)
Tyrosine kinase inhibitors of overexpressed FGFR2 [cytosol]
pazopanib [cytosol]
Overexpressed FGFR2:TKIs [plasma membrane] (Homo sapiens)
Tyrosine kinase inhibitors of overexpressed FGFR2 [cytosol]
pazopanib [cytosol]
Signaling by PDGFR in disease (Homo sapiens)
PDGFR mutants bind TKIs (Homo sapiens)
PDGFR mutants bind type I TKIs (Homo sapiens)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
type I sensitive PDGFR mutants:type I TKIs [plasma membrane] (Homo sapiens)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
RIPK1 is phosphorylated (Homo sapiens)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Homo sapiens)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
RIPK3 is phosphorylated (Homo sapiens)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Homo sapiens)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
Regulation of necroptotic cell death (Homo sapiens)
Small molecule inhibitor binds RIPK1, RIPK3 (Homo sapiens)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Homo sapiens)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PDGF (Homo sapiens)
Autophosphorylation of PDGF alpha receptors (Homo sapiens)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Homo sapiens)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
PDGFRs bind type I TKI (Homo sapiens)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Homo sapiens)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
Programmed Cell Death (Mus musculus)
Regulated Necrosis (Mus musculus)
RIPK1-mediated regulated necrosis (Mus musculus)
RIPK1 is phosphorylated (Mus musculus)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Mus musculus)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
RIPK3 is phosphorylated (Mus musculus)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Mus musculus)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
Regulation of necroptotic cell death (Mus musculus)
Small molecule inhibitor binds RIPK1, RIPK3 (Mus musculus)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Mus musculus)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by PDGF (Mus musculus)
Autophosphorylation of PDGF alpha receptors (Mus musculus)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Mus musculus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
PDGFRs bind type I TKI (Mus musculus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Mus musculus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
Programmed Cell Death (Plasmodium falciparum)
Regulated Necrosis (Plasmodium falciparum)
RIPK1-mediated regulated necrosis (Plasmodium falciparum)
RIPK1 is phosphorylated (Plasmodium falciparum)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Plasmodium falciparum)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
RIPK3 is phosphorylated (Plasmodium falciparum)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Plasmodium falciparum)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
Regulation of necroptotic cell death (Plasmodium falciparum)
Small molecule inhibitor binds RIPK1, RIPK3 (Plasmodium falciparum)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Plasmodium falciparum)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
Programmed Cell Death (Rattus norvegicus)
Regulated Necrosis (Rattus norvegicus)
RIPK1-mediated regulated necrosis (Rattus norvegicus)
RIPK1 is phosphorylated (Rattus norvegicus)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Rattus norvegicus)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
RIPK3 is phosphorylated (Rattus norvegicus)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Rattus norvegicus)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
Regulation of necroptotic cell death (Rattus norvegicus)
Small molecule inhibitor binds RIPK1, RIPK3 (Rattus norvegicus)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Rattus norvegicus)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by PDGF (Rattus norvegicus)
Autophosphorylation of PDGF alpha receptors (Rattus norvegicus)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Rattus norvegicus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
PDGFRs bind type I TKI (Rattus norvegicus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Rattus norvegicus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
Programmed Cell Death (Sus scrofa)
Regulated Necrosis (Sus scrofa)
RIPK1-mediated regulated necrosis (Sus scrofa)
RIPK1 is phosphorylated (Sus scrofa)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Sus scrofa)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
RIPK3 is phosphorylated (Sus scrofa)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Sus scrofa)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
Regulation of necroptotic cell death (Sus scrofa)
Small molecule inhibitor binds RIPK1, RIPK3 (Sus scrofa)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Sus scrofa)
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
pazopanib [cytosol]
Signal Transduction (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by PDGF (Sus scrofa)
Autophosphorylation of PDGF alpha receptors (Sus scrofa)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Sus scrofa)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
PDGFRs bind type I TKI (Sus scrofa)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Sus scrofa)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
pazopanib [cytosol]
External Reference Information
External Reference
pazopanib [Guide to Pharmacology:5698]
Participates
as a member of
Tyrosine kinase inhibitors of overexpressed FGFR2 [cytosol]
Tyrosine kinase inhibitors of FGFR2 mutants [cytosol]
small molecule inhibitors of RIPK1, RIPK3 [cytosol] (Homo sapiens)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
0004992
ChEBI
71219
,
71219
Pharos - Ligands
VAD1FZTYS37A
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