SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu

Stable Identifier
R-HSA-379432
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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SLC7A9 as a heterodimer with SLC3A1 in the plasma membrane mediates the exchange of arginine (L-Arg), lysine (L-Lys), or cystine (CySS-) for leucine (L-Leu) and other neutral amino acids. The physiological concentrations of these amino acids favor neutral amino acid export and arginine/lysine/cystine import. Defects in SLC7A9 and SLC3A1 cause cystinuria. In the body, this transport process is prominent in the kidney (Mizoguchi et al. 2001).
Literature References
PubMed ID Title Journal Year
11318953 Human cystinuria-related transporter: localization and functional characterization

Chairoungdua, A, Cha, SH, Kim, DK, Akakura, K, Matsuo, H, Shigeta, Y, Kanai, Y, Goya, T, Awa, Y, Fukushima, J, Ito, H, Endou, H, Mizoguchi, K

Kidney Int 2001
Participants
Participates
Catalyst Activity

amino acid transmembrane transporter activity of SLC7A9:SLC3A1 [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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