Reactome | SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu

SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu

Stable Identifier

R-HSA-379432

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu

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SLC7A9 as a heterodimer with SLC3A1 in the plasma membrane mediates the exchange of arginine (L-Arg), lysine (L-Lys), or cystine (CySS-) for leucine (L-Leu) and other neutral amino acids. The physiological concentrations of these amino acids favor neutral amino acid export and arginine/lysine/cystine import. Defects in SLC7A9 and SLC3A1 cause cystinuria. In the body, this transport process is prominent in the kidney (Mizoguchi et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11318953	Human cystinuria-related transporter: localization and functional characterization Chairoungdua, A, Cha, SH, Kim, DK, Akakura, K, Matsuo, H, Shigeta, Y, Kanai, Y, Goya, T, Awa, Y, Fukushima, J, Ito, H, Endou, H, Mizoguchi, K	Kidney Int	2001