UniProt:Q96MN2 NLRP4

chain
  • chain:1-994
checksum C2DDA1239274B2D1
comment
  • FUNCTION May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.SUBUNIT Interacts with CHUK/IKKA, inhibiting its kinase activity.ALTERNATIVE PRODUCTS Experimental confirmation may be lacking for some isoforms.DOMAIN The pyrin domain is sufficient for suppression of NF-kappaB activity, it adopts a typical death domain fold, but in contrast to several NLRP family pyrin domains it doesn't bind homotypically to the ASC adapter, which supports the observation that NLRP4 has no effect on IL1B activation.SIMILARITY Belongs to the NLRP family.SEQUENCE CAUTION Truncated C-terminus.
crossReference
databaseName UniProt
dbId 59905
description
  • recommendedName: fullName evidence="12"NACHT, LRR and PYD domains-containing protein 4 alternativeName: Cancer/testis antigen 58 shortName: CT58 alternativeName: PAAD and NACHT-containing protein 2 shortName: PAN2 alternativeName: PYRIN and NACHT-containing protein 2 alternativeName: PYRIN-containing APAF1-like protein 4 shortName: PYPAF4 alternativeName: Ribonuclease inhibitor 2
displayName UniProt:Q96MN2 NLRP4
geneName
  • NLRP4
  • NALP4
  • PAN2
  • PYPAF4
  • RNH2
identifier Q96MN2
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • ATP-binding
  • Inflammatory response
  • Leucine-rich repeat
  • Nucleotide-binding
  • Proteomics identification
  • Reference proteome
  • Repeat
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • NLRP4
otherIdentifier
  • 11755596_a_at
  • 147945
  • 16865789
  • 242334_PM_at
  • 242334_at
  • 3842457
  • 3842458
  • 3842459
  • 3842460
  • 3842461
  • 3842463
  • 3842464
  • 3842465
  • 3842466
  • 3842467
  • 3842468
  • 3842470
  • 3842471
  • 3842472
  • 3842473
  • 3842475
  • 3842476
  • 3842477
  • 3842478
  • 3842479
  • 3842480
  • 42793_at
  • 8031576
  • A_14_P127519
  • A_23_P164966
  • A_33_P3406047
  • GE80604
  • GO:0000166
  • GO:0005515
  • GO:0005524
  • GO:0005737
  • GO:0005829
  • GO:0006954
  • GO:0030163
  • GO:0043161
  • GO:0045824
  • GO:0050727
  • GO:0060090
  • GO:0070936
  • GO:0140374
  • GO:1990168
  • HMNXSV003010301
  • Hs.164851.0.A1_3p_at
  • ILMN_1746820
  • PH_hs_0032797
  • TC19000913.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • NALP4_HUMAN
  • Q86W87
  • Q96AY6
sequenceLength 994
species [Species:48887] Homo sapiens
stId uniprot:Q96MN2
url http://purl.uniprot.org/uniprot/Q96MN2
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