UniProt:Q6WCQ1 MPRIP

chain
  • initiator methionine:1
  • chain:2-1025
checksum 5B7A30CDB3685E4E
comment
  • FUNCTION Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.SUBUNIT Binds F-actin through its N-terminus. Interacts with MYZAP (By similarity). Binds RHOA, PPP1R12A/MBS and PPP1R12C/MBS85 through adjacent coiled coil domains.INTERACTION Colocalizes with F-actin.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 237886
description
  • recommendedName: Myosin phosphatase Rho-interacting protein shortName: M-RIP alternativeName: Rho-interacting protein 3 shortName: RIP3 alternativeName: p116Rip
displayName UniProt:Q6WCQ1 MPRIP
geneName
  • MPRIP
  • KIAA0864
  • MRIP
  • RHOIP3
identifier Q6WCQ1
isSequenceChanged false
keyword
  • Actin-binding
  • Alternative splicing
  • Coiled coil
  • Cytoplasm
  • Cytoskeleton
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • MPRIP
otherIdentifier
  • 11717546_s_at
  • 11739524_a_at
  • 16831562
  • 212197_PM_x_at
  • 212197_x_at
  • 214694_PM_at
  • 214694_at
  • 214771_PM_x_at
  • 214771_x_at
  • 225896_PM_at
  • 225896_at
  • 231255_PM_at
  • 231255_at
  • 23164
  • 238328_PM_at
  • 238328_at
  • 2671507
  • 2671508
  • 2671509
  • 2671510
  • 2671512
  • 2671513
  • 2671514
  • 2671515
  • 2671516
  • 2671519
  • 2671520
  • 2671550
  • 3712364
  • 3712365
  • 3712370
  • 3712376
  • 3712378
  • 3712386
  • 3712387
  • 3712397
  • 3712400
  • 3712404
  • 3712405
  • 3712406
  • 3712408
  • 3712409
  • 3712410
  • 3712412
  • 3712413
  • 3712414
  • 3712415
  • 3712416
  • 3712417
  • 3712418
  • 3712419
  • 3712422
  • 3712423
  • 3712427
  • 3712428
  • 3712429
  • 3712431
  • 3712432
  • 3712435
  • 3712436
  • 3712437
  • 3712438
  • 3712439
  • 3712440
  • 3712441
  • 3712442
  • 3712443
  • 3712448
  • 3712449
  • 3712450
  • 3712451
  • 3712452
  • 3712453
  • 3712455
  • 3712456
  • 3712457
  • 3712458
  • 3712459
  • 3712461
  • 3712463
  • 3712464
  • 3712471
  • 3712472
  • 3712473
  • 3712474
  • 3712475
  • 3712476
  • 3712478
  • 3712482
  • 3712484
  • 3712485
  • 3712486
  • 38730_at
  • 38731_at
  • 51061_at
  • 52146_at
  • 8005235
  • 81343_s_at
  • 8180362
  • 8180363
  • A_14_P139213
  • A_19_P00317887
  • A_19_P00803575
  • A_19_P00811812
  • A_23_P15348
  • A_23_P394014
  • A_32_P105976
  • A_33_P3230528
  • A_33_P3230541
  • D23673_at
  • GE53547
  • GE84152
  • GO:0003779
  • GO:0005515
  • GO:0005737
  • GO:0005829
  • GO:0005856
  • GO:0005925
  • GO:0008092
  • GO:0015629
  • GO:0045296
  • GO:0051015
  • HMNXSV003002403
  • HMNXSV003006205
  • HMNXSV003013470
  • Hs.156823.0.A1_3p_at
  • Hs.159336.0.A1_3p_at
  • Hs.46783.0.S1_3p_at
  • Hs.84883.0.A1_3p_a_at
  • ILMN_1678692
  • ILMN_1774547
  • ILMN_1836776
  • ILMN_1905780
  • PH_hs_0025217
  • PH_hs_0040745
  • TC17000194.hg
  • TC17002083.hg
  • TC17002084.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • MPRIP_HUMAN
  • Q3KQZ5
  • Q5FB94
  • Q6DHW2
  • Q7Z5Y2
  • Q8N390
  • Q96G40
sequenceLength 1025
species [Species:48887] Homo sapiens
stId uniprot:Q6WCQ1
url http://purl.uniprot.org/uniprot/Q6WCQ1
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