UniProt:Q13185 CBX3

chain
  • initiator methionine:1
  • chain:2-183
checksum 5928C63E0C93A76A
comment
  • FUNCTION Component of heterochromatin, which recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression (PubMed:11242053). Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me) (PubMed:16127177). Excluded from chromatin when histone H1.4 is Simultaneously methylated at Lys-26 (H1.4K26me) and phosphorylated at Ser-27 (H1.4S27Ph) (PubMed:16127177). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (PubMed:15502821). Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1 (By similarity). Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679).SUBUNIT Binds directly to CHAF1A. Interacts with histone H3 methylated at 'Lys-9' (PubMed:11242053). Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with INCENP, TRIM28/TIF1B, KMT5B, KMT5C and SP100 (PubMed:10330177, PubMed:12004135, PubMed:9636146). Interacts with TIF1A (By similarity). Interacts with MIS12 and DSN1 (PubMed:15502821). Can interact directly with CBX5 via the chromoshadow domain (PubMed:9169472). Interacts with POGZ (PubMed:20562864, PubMed:20850016). Interacts with CHAMP1 (PubMed:20850016). The large PER complex involved in the histone methylation is composed of at least PER2, CBX3, TRIM28, SUV39H1 and/or SUV39H2; CBX3 mediates the formation of the complex. Interacts with INCENP (PubMed:21346195, PubMed:9864353). Interacts with NIPBL (via PxVxL motif) (PubMed:28167679). Interacts with LRIF1 (via PxVxL motif) (PubMed:23542155). Interacts with TTLL12 (PubMed:23251473). Interacts with ZNF263; recruited to the SIX3 promoter along with other proteins involved in chromatin modification and transcriptional corepression where it contributes to transcriptional repression (PubMed:32051553). Interacts with CHD3 (PubMed:28977666). Interacts with CHD4 (PubMed:28977666).INTERACTION Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential).PTM Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.CAUTION Was previously reported to interact with ASXL1. However, this publication has been retracted.
crossReference
databaseName UniProt
dbId 51520
description
  • recommendedName: Chromobox protein homolog 3 alternativeName: HECH alternativeName: Heterochromatin protein 1 homolog gamma shortName: HP1 gamma alternativeName: Modifier 2 protein
displayName UniProt:Q13185 CBX3
geneName
  • CBX3
identifier Q13185
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Biological rhythms
  • Chromatin regulator
  • Direct protein sequencing
  • Isopeptide bond
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Repressor
  • Transcription
  • Transcription regulation
  • Ubl conjugation
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • CBX3
otherIdentifier
  • 11335
  • 11715499_x_at
  • 11754967_s_at
  • 1555920_PM_at
  • 1555920_at
  • 16654801
  • 16654803
  • 16654809
  • 16654811
  • 16654813
  • 16654815
  • 16654821
  • 16654823
  • 16654825
  • 17044423
  • 18670410
  • 18670411
  • 18670412
  • 18670413
  • 18670414
  • 18670415
  • 18670416
  • 18670417
  • 18670418
  • 18670419
  • 200037_PM_s_at
  • 200037_s_at
  • 201091_PM_s_at
  • 201091_s_at
  • 230998_PM_at
  • 230998_at
  • 2971087
  • 2993638
  • 2993640
  • 2993641
  • 2993642
  • 2993643
  • 2993644
  • 2993646
  • 2993647
  • 2993648
  • 2993649
  • 2993650
  • 2993651
  • 2993653
  • 2993654
  • 2993655
  • 2993656
  • 2993657
  • 2993658
  • 2993659
  • 2993660
  • 2993684
  • 2993696
  • 2993700
  • 2993702
  • 2993704
  • 2993706
  • 38084_at
  • 38085_at
  • 47980_at
  • 54190_at
  • 61813_at
  • 73344_s_at
  • 7892699
  • 7892814
  • 7893226
  • 7893313
  • 7893451
  • 7893575
  • 7893715
  • 7893722
  • 7894211
  • 7894834
  • 7894927
  • 7895252
  • 7895322
  • 7895358
  • 7895717
  • 7896618
  • 8131949
  • 82714_at
  • 89994_r_at
  • A_23_P31315
  • GE53763
  • GE84027
  • GO:0000775
  • GO:0000779
  • GO:0000781
  • GO:0000785
  • GO:0000791
  • GO:0000792
  • GO:0001221
  • GO:0003682
  • GO:0005515
  • GO:0005634
  • GO:0005635
  • GO:0005637
  • GO:0005654
  • GO:0005721
  • GO:0005819
  • GO:0006325
  • GO:0006338
  • GO:0006355
  • GO:0006974
  • GO:0019899
  • GO:0019904
  • GO:0031507
  • GO:0035985
  • GO:0042802
  • GO:0043226
  • GO:0045892
  • GO:0048511
  • GO:0061793
  • GO:0071549
  • GO:0090575
  • GO:0090734
  • GO:1990226
  • HMNXSV003009753
  • HMNXSV003054584
  • Hs.145199.0.A1_3p_at
  • Hs.145199.0.A1_3p_x_at
  • Hs.278554.0.A1_3p_x_at
  • Hs2.411153.1.A1_3p_at
  • ILMN_1774086
  • ILMN_1782173
  • ILMN_1790625
  • PH_hs_0024337
  • TC07000160.hg
  • TC07002203.hg
  • U26312_s_at
  • g7705406_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CBX3_HUMAN
  • Q96CD7
  • Q99409
  • Q9BVS3
  • Q9P0Z6
sequenceLength 183
species [Species:48887] Homo sapiens
stId uniprot:Q13185
url http://purl.uniprot.org/uniprot/Q13185

Referrals

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