Reactome | UniProt:P23588 EIF4B

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UniProt:P23588 EIF4B Show undefined attributes

chain	chain:1-611
checksum	31CEFEA865FB10D2
comment	FUNCTION Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.SUBUNIT Self-associates and interacts with EIF3 p170 subunit.INTERACTION Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1; phosphorylation enhances the affinity of EIF4B for the EIF3 complex. In response to mTORC1 activation, RPS6KA1-mediated phosphorylation at 'Ser-406' and 'Ser-422' stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function.
crossReference	[DatabaseIdentifier:12378487] RefSeq:NP_001408.2 [DatabaseIdentifier:12378486] RefSeq:NP_001317583.1 [DatabaseIdentifier:12288288] Pharos - Targets:P23588 [DatabaseIdentifier:12269669] PRO:P23588 [DatabaseIdentifier:12203259] PDB:2J76 [DatabaseIdentifier:12203260] PDB:1WI8 [DatabaseIdentifier:12156080] PDB:6FEC [DatabaseIdentifier:12128064] OpenTargets:ENSG00000063046 [DatabaseIdentifier:11843454] HPA:ENSG00000063046-EIF4B [DatabaseIdentifier:11806364] GlyGen:P23588 [DatabaseIdentifier:11790446] GeneCards:EIF4B [DatabaseIdentifier:11699253] ENSEMBL:ENST00000262056 [DatabaseIdentifier:11699252] ENSEMBL:ENST00000416762 [DatabaseIdentifier:11576553] ENSEMBL:ENSP00000262056 [DatabaseIdentifier:11576554] ENSEMBL:ENSP00000412530 [DatabaseIdentifier:11476980] ENSEMBL:ENSG00000063046
databaseName	UniProt
dbId	72588
description	recommendedName: Eukaryotic translation initiation factor 4B shortName: eIF-4B
displayName	UniProt:P23588 EIF4B
geneName	EIF4B
identifier	P23588
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing Direct protein sequencing Initiation factor Isopeptide bond Phosphoprotein Protein biosynthesis Proteomics identification Reference proteome RNA-binding Ubl conjugation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	EIF4B
otherIdentifier	11747066_x_at 11752470_s_at 11752757_s_at 11752758_x_at 11756144_s_at 16751570 1975 211937_PM_at 211937_at 211938_PM_at 211938_at 2639039 2660283 2999321 3017474 3017478 3017482 3017483 3017484 3017486 3017487 3017488 3017489 3017491 3017492 3017493 3017494 3017495 3017496 3180872 3180876 3180877 3180878 3180879 3415618 3415622 3415625 3415626 3415627 3415629 3415630 3415631 3415632 3415633 3415634 3415637 3415639 3415640 3415641 3415642 3415643 3415644 3415645 3415646 3415647 3415648 3415649 3415650 3415651 3415652 3415653 3415654 3415655 3415657 3415658 3415659 3415660 3415661 3415662 39110_at 4018280 4018281 4018282 4018283 4018285 4018286 4018288 4018289 4018291 4018292 4018293 4018294 4018295 4018298 7955646 8135268 87803_s_at A_23_P162679 A_24_P218970 GE81018 GE84662 GE85788 GO:0001731 GO:0003676 GO:0003723 GO:0003743 GO:0005515 GO:0005829 GO:0006412 GO:0006413 GO:0006446 GO:0016281 GO:0033592 GO:0034057 GO:0043024 GO:0065003 GO:0097010 HMNXSV003014771 Hs.283330.1.S1_3p_s_at Hs.93379.0.S1_3p_at ILMN_1655497 PH_hs_0031414 TC12000425.hg X55733_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-165773] p-S422-EIF4B [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-72589] EIF4B [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12690131] UCSC:P23588 EIF4B [ReferenceDNASequence:12112871] OMIM:603928 EIF4B [ReferenceDNASequence:12056290] NCBI Gene:1975 EIF4B [ReferenceDNASequence:11972197] Monarch:1975 EIF4B [ReferenceDNASequence:11882984] KEGG:hsa:1975 EIF4B [ReferenceDNASequence:11822107] HGNC:3285 EIF4B [ReferenceDNASequence:11428827] dbSNP Gene:1975 EIF4B [ReferenceDNASequence:11417822] CTD Gene:1975 EIF4B [ReferenceDNASequence:11392913] COSMIC - genes:EIF4B EIF4B [ReferenceDNASequence:11342408] BioGPS Gene:1975 EIF4B [ReferenceDNASequence:ensembl:ENSG00000063046] ENSEMBL:ENSG00000063046 EIF4B
referenceTranscript	[ReferenceRNASequence:12560270] RefSeq:NM_001417.7 EIF4B [ReferenceRNASequence:12560269] RefSeq:NM_001330654.2 EIF4B
schemaClass	ReferenceGeneProduct
secondaryIdentifier	IF4B_HUMAN B4DS13 Q4G0E3 Q53HQ2 Q6GPH5 Q6IB46 Q8WYK5
sequenceLength	611
species	[Species:48887] Homo sapiens
stId	uniprot:P23588
url	http://purl.uniprot.org/uniprot/P23588

Referrals

(interactor)	[UndirectedInteraction:11232649] UniProt:P23588 <-> UniProt:P61981 (IntAct) [UndirectedInteraction:11232647] UniProt:P23588 <-> UniProt:O75821 (IntAct) [UndirectedInteraction:11232645] UniProt:P23588 <-> UniProt:P53350 (IntAct) [UndirectedInteraction:11232643] UniProt:P23588 <-> IntAct:EBI-1108795 (IntAct) [UndirectedInteraction:11232641] UniProt:P23588 <-> UniProt:Q9BSI4 (IntAct) [UndirectedInteraction:11232639] UniProt:P23588 <-> UniProt:Q86V38 (IntAct) [UndirectedInteraction:11232637] UniProt:P23588 <-> UniProt:P02489 (IntAct) [UndirectedInteraction:11232635] UniProt:P23588 <-> UniProt:Q92876 (IntAct) [UndirectedInteraction:11232633] UniProt:P23588 <-> UniProt:Q14152 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-165773] p-S422-EIF4B [cytosol] [EntityWithAccessionedSequence:R-HSA-72589] EIF4B [cytosol]
(referenceSequence)	[ModifiedResidue:165772] O-phospho-L-serine at 422