Reactome | UniProt:P23193 TCEA1

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UniProt:P23193 TCEA1 Show undefined attributes

chain	chain:1-301
checksum	8A685107A56D2DA1
comment	FUNCTION Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.SUBUNIT Interacts with EAF2 (By similarity). Associates with UBR5 and forms a transcription regulatory complex made of CDK9, Pol II, UBR5 and TCEA1/TFIIS (PubMed:21127351). Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms (PubMed:27193682).INTERACTION Additional isoforms seem to exist.DISEASE A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1.MISCELLANEOUS S-II binds to RNA-polymerase II in the absence of transcription.SIMILARITY Belongs to the TFS-II family.
crossReference	[DatabaseIdentifier:12148639] PDB:9EGZ [DatabaseIdentifier:12372981] RefSeq:NP_006747.1 [DatabaseIdentifier:12372982] RefSeq:NP_958845.1 [DatabaseIdentifier:12286856] Pharos - Targets:P23193 [DatabaseIdentifier:12267052] PRO:P23193 [DatabaseIdentifier:11474352] ENSEMBL:ENSG00000187735 [DatabaseIdentifier:11573055] ENSEMBL:ENSP00000395483 [DatabaseIdentifier:11573056] ENSEMBL:ENSP00000428426 [DatabaseIdentifier:11695755] ENSEMBL:ENST00000521604 [DatabaseIdentifier:11695754] ENSEMBL:ENST00000396401 [DatabaseIdentifier:11788982] GeneCards:TCEA1 [DatabaseIdentifier:11804612] GlyGen:P23193 [DatabaseIdentifier:11842008] HPA:ENSG00000187735-TCEA1 [DatabaseIdentifier:12126602] OpenTargets:ENSG00000187735 [DatabaseIdentifier:12148643] PDB:9EH0 [DatabaseIdentifier:12148640] PDB:9EGX [DatabaseIdentifier:12148641] PDB:7UNC [DatabaseIdentifier:12138273] PDB:5IYB [DatabaseIdentifier:12188059] PDB:6ZUY [DatabaseIdentifier:12138288] PDB:6O9L [DatabaseIdentifier:12148642] PDB:7UND [DatabaseIdentifier:12188060] PDB:7CNF [DatabaseIdentifier:12147591] PDB:9EH2 [DatabaseIdentifier:12138282] PDB:5IY7 [DatabaseIdentifier:12164224] PDB:8A40 [DatabaseIdentifier:12138280] PDB:5IY6 [DatabaseIdentifier:12188057] PDB:3NDQ [DatabaseIdentifier:12163925] PDB:6ZV4 [DatabaseIdentifier:12139958] PDB:9J0N [DatabaseIdentifier:12138278] PDB:5IYC [DatabaseIdentifier:12148638] PDB:9EGY [DatabaseIdentifier:12138281] PDB:5IY8 [DatabaseIdentifier:12188058] PDB:1TFI [DatabaseIdentifier:12138275] PDB:5IYA [DatabaseIdentifier:12164216] PDB:8UIS
databaseName	UniProt
dbId	65749
description	recommendedName: Transcription elongation factor A protein 1 alternativeName: Transcription elongation factor S-II protein 1 alternativeName: Transcription elongation factor TFIIS.o
displayName	UniProt:P23193 TCEA1
geneName	TCEA1 GTF2S TFIIS
identifier	P23193
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing Chromosomal rearrangement Direct protein sequencing DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	TCEA1
otherIdentifier	1073_at 11734918_s_at 11734919_s_at 11752908_a_at 133039973 17077222 216241_PM_s_at 216241_s_at 2617135 2617136 2617137 2617138 2617139 2617140 2617141 3135531 3135533 3135534 3135541 3135542 3135544 3135547 3135548 3135549 3135550 3135551 3135552 3135553 3135554 3135555 3135556 3135557 3135558 6917 8078600 8150818 A_23_P132444 A_24_P126651 GE58095 GE59984 GO:0003676 GO:0003677 GO:0003746 GO:0005515 GO:0005634 GO:0005654 GO:0005669 GO:0005730 GO:0006351 GO:0006355 GO:0006366 GO:0006368 GO:0006414 GO:0008270 GO:0030154 GO:0030218 GO:0045893 GO:0045944 GO:0046872 HMNXSV003006625 Hs.78869.1.S1_3p_a_at ILMN_1698139 ILMN_1709851 ILMN_2357770 M81601_at PH_hs_0027158 TC08001216.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-65748] TCEA1 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000187735] ENSEMBL:ENSG00000187735 TCEA1 [ReferenceDNASequence:12688111] UCSC:P23193 TCEA1 [ReferenceDNASequence:11339599] BioGPS Gene:6917 TCEA1 [ReferenceDNASequence:11392823] COSMIC - genes:TCEA1 TCEA1 [ReferenceDNASequence:11415486] CTD Gene:6917 TCEA1 [ReferenceDNASequence:11428712] dbSNP Gene:6917 TCEA1 [ReferenceDNASequence:11820634] HGNC:11612 TCEA1 [ReferenceDNASequence:11880448] KEGG:hsa:6917 TCEA1 [ReferenceDNASequence:11969388] Monarch:6917 TCEA1 [ReferenceDNASequence:12053481] NCBI Gene:6917 TCEA1 [ReferenceDNASequence:12111581] OMIM:601425 TCEA1
referenceTranscript	[ReferenceRNASequence:12554759] RefSeq:NM_006756.4 TCEA1 [ReferenceRNASequence:12554758] RefSeq:NM_201437.3 TCEA1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	TCEA1_HUMAN A6NF25 A8K339 Q15563 Q6FG87
sequenceLength	301
species	[Species:48887] Homo sapiens
stId	uniprot:P23193
url	http://purl.uniprot.org/uniprot/P23193

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[EntityWithAccessionedSequence:R-HSA-65748] TCEA1 [nucleoplasm]

(interactor)