UniProt:P12841 Fos

chain
  • chain:1-380
checksum E62D16A88CB2BEE9
comment
  • FUNCTION Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity).SUBUNIT Heterodimer; with JUN (By similarity). Component of the SMAD3/SMAD4/JUN/FOS complex required for synergistic TGF-beta-mediated transcription at the AP1-binding site (By similarity). Interacts with SMAD3; the interaction is weak even on TGF-beta activation (By similarity). Interacts with MAFB (PubMed:9571165). Interacts with TSC22D3 (via N-terminus); this interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with CDS1 and PI4K2A (By similarity). Interacts (via bZIP domain and leucine-zipper region) with the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF) subunits SMARCB1, SMARCC2 and SMARCD1 (By similarity). Interacts (via bZIP domain and leucine-zipper region) with ARID1A (By similarity).INTERACTION In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30 (By similarity).PTM Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF) (By similarity). Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on both Ser-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to protein stabilization with phosphorylation on Ser-374 being the major site for protein stabilization on NGF stimulation. Phosphorylation on Ser-362 and Ser-374 primes further phosphorylations on Thr-325 and Thr-331 through promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-232, induced by HA-RAS, activates the transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-362 by RSK2 in osteoblasts contributes to osteoblast transformation.PTM Constitutively sumoylated with SUMO1, SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional activity and is, itself, inhibited by Ras-activated phosphorylation on Thr-232 (By similarity).PTM In quiescent cells, the small amount of FOS present is phosphorylated at Tyr-10 and Tyr-30 by SRC. This Tyr-phosphorylated form is cytosolic. In growing cells, dephosphorylated by PTPN2. Dephosphorylation leads to the association with endoplasmic reticulum membranes and activation of phospholipid synthesis (By similarity).SIMILARITY Belongs to the bZIP family. Fos subfamily.
crossReference
databaseName UniProt
dbId 90546
description
  • recommendedName: fullName evidence="9"Protein c-Fos alternativeName: Cellular oncogene fos alternativeName: fullName evidence="9"Proto-oncogene c-Fos
displayName UniProt:P12841 Fos
geneName
  • Fos
identifier P12841
isSequenceChanged false
keyword
  • Cytoplasm
  • DNA-binding
  • Endoplasmic reticulum
  • Isopeptide bond
  • Nucleus
  • Phosphoprotein
  • Proto-oncogene
  • Reference proteome
  • Ubl conjugation
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • Fos
otherIdentifier
  • 10886031
  • 1375043_at
  • 17817508
  • 314322
  • 5644370
  • 5709826
  • 5738378
  • 5865157
  • 5917432
  • 5941994
  • 6346538
  • A_44_P495480
  • A_64_P131051
  • GE16552
  • GE18981
  • GE22096
  • GO:0000976
  • GO:0000978
  • GO:0000979
  • GO:0001221
  • GO:0001228
  • GO:0003677
  • GO:0003682
  • GO:0003700
  • GO:0005634
  • GO:0005654
  • GO:0005667
  • GO:0005737
  • GO:0005783
  • GO:0006351
  • GO:0006355
  • GO:0006357
  • GO:0006366
  • GO:0007179
  • GO:0007399
  • GO:0009410
  • GO:0010468
  • GO:0030154
  • GO:0030316
  • GO:0032993
  • GO:0034614
  • GO:0035914
  • GO:0035976
  • GO:0035994
  • GO:0042802
  • GO:0045672
  • GO:0045893
  • GO:0045944
  • GO:0048856
  • GO:0060395
  • GO:0061629
  • GO:0070412
  • GO:0071277
  • GO:0090575
  • GO:1902895
  • GO:1990837
  • ILMN_1368356
  • PH_rn_0011802
  • X03347cds_g_at
  • X06769cds_at
  • X06769cds_g_at
  • rc_AI072183_at
  • rc_AI176185_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • FOS_RAT
  • Q4FDN1
sequenceLength 380
species [Species:48895] Rattus norvegicus
stId uniprot:P12841
url http://purl.uniprot.org/uniprot/P12841
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