Reactome | UniProt:P11831 SRF

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UniProt:P11831 SRF Show undefined attributes

chain	chain:1-508
checksum	25505828D3276F44
comment	FUNCTION SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation.SUBUNIT Binds DNA as a multimer, probably a dimer (PubMed:7637780). Interacts with MRTFA, forming the SRF-MRTFA nuclear complex which binds the 5'-CArG-3' consensus motif (CArG box) on DNA via SRF (PubMed:14565952, PubMed:19350017). Forms a nuclear ternary complex with MRTFA and SCAI (PubMed:19350017). Interacts with MRTFB (PubMed:14565952). Interacts with MLLT7/FOXO4, NKX3A and SSRP1 (PubMed:16054032). Interacts with ARID2 (By similarity). Interacts with SRFBP1 (By similarity). Interacts with FOXK1 (PubMed:17670796). Interacts with LPXN (PubMed:18497331). Interacts with OLFM2; the interaction promotes dissociation of SRF from the transcriptional repressor HEY2, facilitates binding of SRF to target genes and promotes smooth muscle differentiation (PubMed:25298399). Interacts with NKX3-1 (By similarity). Interacts with KAT5 (By similarity). Interacts with PURB (By similarity).INTERACTION Phosphorylated by PRKDC.
crossReference	[DatabaseIdentifier:12471435] RefSeq:NP_001278930.1 [DatabaseIdentifier:12471434] RefSeq:NP_003122.1 [DatabaseIdentifier:12289706] Pharos - Targets:P11831 [DatabaseIdentifier:12271851] PRO:P11831 [DatabaseIdentifier:12210233] PDB:1K6O [DatabaseIdentifier:12210234] PDB:1SRS [DatabaseIdentifier:12210235] PDB:1HBX [DatabaseIdentifier:12129495] OpenTargets:ENSG00000112658 [DatabaseIdentifier:11844860] HPA:ENSG00000112658-SRF [DatabaseIdentifier:11807863] GlyGen:P11831 [DatabaseIdentifier:11791863] GeneCards:SRF [DatabaseIdentifier:11762988] ENSEMBL:ENST00000265354 [DatabaseIdentifier:11640289] ENSEMBL:ENSP00000265354 [DatabaseIdentifier:11521039] ENSEMBL:ENSG00000112658
databaseName	UniProt
dbId	65052
description	recommendedName: Serum response factor shortName: SRF
displayName	UniProt:P11831 SRF
geneName	SRF
identifier	P11831
isSequenceChanged	false
keyword	3D-structure Activator Developmental protein Direct protein sequencing DNA-binding Glycoprotein Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	SRF
otherIdentifier	11737486_s_at 11746117_a_at 1409_at 17008856 202400_PM_s_at 202400_s_at 202401_PM_s_at 202401_s_at 2907731 2907732 2907733 2907734 2907735 2907736 2907737 2907738 2907739 2907742 2907743 2907744 2907745 2907746 2907750 2907751 2907752 2907753 2907755 40109_at 6722 8119712 A_23_P111020 A_24_P337657 A_24_P346277 GE57476 GO:0000785 GO:0000978 GO:0000981 GO:0000987 GO:0001228 GO:0001569 GO:0001666 GO:0001701 GO:0001707 GO:0001764 GO:0001829 GO:0001947 GO:0002011 GO:0002042 GO:0002376 GO:0002521 GO:0003677 GO:0003682 GO:0003700 GO:0003723 GO:0005515 GO:0005634 GO:0005654 GO:0005737 GO:0006351 GO:0006355 GO:0006366 GO:0007015 GO:0007155 GO:0007160 GO:0007369 GO:0007507 GO:0007616 GO:0008285 GO:0008306 GO:0009636 GO:0009725 GO:0010669 GO:0010736 GO:0021766 GO:0022028 GO:0030036 GO:0030038 GO:0030154 GO:0030155 GO:0030168 GO:0030220 GO:0030336 GO:0030878 GO:0030900 GO:0031175 GO:0031490 GO:0034097 GO:0034330 GO:0035855 GO:0035912 GO:0042060 GO:0042803 GO:0042826 GO:0043149 GO:0043565 GO:0043589 GO:0045059 GO:0045214 GO:0045597 GO:0045773 GO:0045893 GO:0045944 GO:0045987 GO:0046016 GO:0046716 GO:0046847 GO:0046983 GO:0048538 GO:0048589 GO:0048666 GO:0048675 GO:0048821 GO:0048856 GO:0048870 GO:0050877 GO:0051091 GO:0051150 GO:0051491 GO:0055003 GO:0060055 GO:0060218 GO:0060261 GO:0060292 GO:0060324 GO:0060347 GO:0060379 GO:0060425 GO:0060532 GO:0060534 GO:0060947 GO:0061029 GO:0061145 GO:0061436 GO:0061629 GO:0070830 GO:0070878 GO:0071333 GO:0090009 GO:0090136 GO:0090398 GO:0098609 GO:0140297 GO:1900222 GO:1902894 GO:1902895 GO:1990837 HMNXSV003003408 Hs.155321.0.A1_3p_a_at ILMN_1803398 J03161_at PH_hs_0025942 TC06000596.hg g4507204_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-9612518] p-S103 SRF [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5666000] SRF [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12715704] UCSC:P11831 SRF [ReferenceDNASequence:12114135] OMIM:600589 SRF [ReferenceDNASequence:12098798] NCBI Gene:6722 SRF [ReferenceDNASequence:12014705] Monarch:6722 SRF [ReferenceDNASequence:11921499] KEGG:hsa:6722 SRF [ReferenceDNASequence:11823538] HGNC:11291 SRF [ReferenceDNASequence:11432783] dbSNP Gene:6722 SRF [ReferenceDNASequence:11419770] CTD Gene:6722 SRF [ReferenceDNASequence:11396358] COSMIC - genes:SRF SRF [ReferenceDNASequence:11384916] BioGPS Gene:6722 SRF [ReferenceDNASequence:ensembl:ENSG00000112658] ENSEMBL:ENSG00000112658 SRF
referenceTranscript	[ReferenceRNASequence:12652902] RefSeq:NM_001292001.1 SRF [ReferenceRNASequence:12652903] RefSeq:NM_003131.4 SRF
schemaClass	ReferenceGeneProduct
secondaryIdentifier	SRF_HUMAN Q5T648
sequenceLength	508
species	[Species:48887] Homo sapiens
stId	uniprot:P11831
url	http://purl.uniprot.org/uniprot/P11831

Referrals

(interactor)	[UndirectedInteraction:11153285] UniProt:P11831 <-> UniProt:Q8IZQ8 (IntAct) [UndirectedInteraction:11153283] UniProt:P11831 <-> UniProt:P15173 (IntAct) [UndirectedInteraction:11153281] UniProt:P11831 <-> UniProt:P15172 (IntAct) [UndirectedInteraction:11153279] UniProt:P11831 <-> UniProt:Q969V6 (IntAct) [UndirectedInteraction:11153277] UniProt:P11831 <-> UniProt:Q9ULH7 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-9612518] p-S103 SRF [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5666000] SRF [nucleoplasm]
(referenceSequence)	[ModifiedResidue:9612519] O-phospho-L-serine at 103