UniProt:P10408 secA

chain
  • chain:1-901
checksum 683D66DD4305DBC2
comment
  • FUNCTION Required for protein export, interacts with the SecYEG preprotein conducting channel. SecA has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.CATALYTIC ACTIVITY ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.COFACTOR Binds 1 zinc ion per subunit. Zinc is required for binding of the SecB chaperone to the extreme C-terminus of SecA.ACTIVITY REGULATION The translocation ATPase activity is stimulated by SecY and a precursor protein such as proOmpA.SUBUNIT Monomer and homodimer; probably dimeric in the cytoplasm. It is not yet clear whether the form that functions in protein insertion is monomeric or dimeric. Part of the essential protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC. Makes direct contact with SecY.INTERACTION Distribution is 50-50.INDUCTION Repressed under conditions of excess protein secretion capacity and derepressed when protein secretion becomes limiting. This is regulated by SecM.DISRUPTION PHENOTYPE Essential. Leads to loss of translocation of lipoproteins Lpp and BRP.SIMILARITY Belongs to the SecA family.
created [InstanceEdit:9760325] Stephan, Ralf, 2021-12-16
crossReference
databaseName UniProt
dbId 9760337
description
  • recommendedName: fullName evidence="1 11"Protein translocase subunit SecA ecNumber evidence="1 6 9 12"7.4.2.8
displayName UniProt:P10408 secA
geneName
  • secA
  • azi
  • pea
  • prlD
  • b0098
  • JW0096
identifier P10408
isSequenceChanged false
keyword
  • 3D-structure
  • ATP-binding
  • Cell inner membrane
  • Cell membrane
  • Cytoplasm
  • Direct protein sequencing
  • Membrane
  • Metal-binding
  • Nucleotide-binding
  • Protein transport
  • Reference proteome
  • Translocase
  • Translocation
  • Transport
  • Zinc
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • secA
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • SECA_ECOLI
  • P75642
sequenceLength 901
species [Species:159879] Escherichia coli
stId uniprot:P10408
url http://purl.uniprot.org/uniprot/P10408
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