Reactome | UniProt:P0DTC3 3a

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UniProt:P0DTC3 3a Show undefined attributes

chain	chain:1-275
checksum	4688E6D477E031C4
comment	FUNCTION Plays a role in viral egress via lysosomal trafficking (PubMed:33157038, PubMed:33422265). Forms homotetrameric ion channels (viroporins) localized at endosomes and lysosomes, that may induce deacidification of lysosomes, allowing safe egress of virions via lysosomal trafficking (PubMed:33157038, PubMed:33422265, PubMed:34158638). Also blocks autolysosome formation by binding and sequestering the host component VPS39 for homotypic fusion and protein sorting (HOPS) on late endosomes (PubMed:33422265). This prevents fusion of autophagosomes with lysosomes, disrupting autophagy and facilitating virus egress (PubMed:33422265). Induces host RETREG1/FAM134B-dependent reticulophagy by interacting with host HMGB1 and enhancing the association between HMGB1 and host BECN1 (PubMed:35239449). This induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449).SUBUNIT Homodimer (PubMed:34158638), a subset forms homotetramer of two homodimers linked non covalently (PubMed:34158638). Interacts with M, S and E proteins. Also interacts with the accessory protein 7a (By similarity). Interacts with host VPS39, sequestering it on late endosomes (PubMed:33422265). Interacts with host HMGB1; the interaction enhances the association between HMGB1 and host BECN1, promoting reticulophagy (PubMed:35239449). Interacts with HMOX1; the interaction promotes ORF3A-induced autophagy but is unlikely to be involved in ORF3A-mediated induction of reticulophagy (PubMed:35239449).INTERACTION The cell surface expressed protein can undergo endocytosis. The protein is secreted in association with membranous structures.DOMAIN The second or the third transmembrane region are responsible for Golgi localization.PTM Exists in both O-glycosylated and non-glycosylated forms. The glycosylated form is associated with the virion.POLYMORPHISM Variant Omicron/BA.1 and BA.2 belong to a lineage first isolated in South Africa (November 2021).POLYMORPHISM Variant Omicron/BQ.1.1 belongs to a lineage first isolated in Nigeria (November 2022).POLYMORPHISM Variant Omicron/XBB.1.5 belongs to a lineage first isolated in United States (November 2022). It is the result of recombination between omicron BJ.1 and BM.1.1. Moreover XBB.1.5 do not express ORF8.
created	[InstanceEdit:9681685] D'Eustachio, Peter, 2020-04-03
crossReference	[DatabaseIdentifier:11806239] GlyGen:P0DTC3 [DatabaseIdentifier:12175817] PDB:8T5Q [DatabaseIdentifier:12176486] PDB:7KJR [DatabaseIdentifier:12197837] PDB:9RU5 [DatabaseIdentifier:12197839] PDB:8EQT [DatabaseIdentifier:12197841] PDB:8EQJ [DatabaseIdentifier:12197842] PDB:8T5P [DatabaseIdentifier:12197838] PDB:6XDC [DatabaseIdentifier:12197840] PDB:8EQU
databaseName	UniProt
dbId	9681697
description	recommendedName: ORF3a protein shortName: ORF3a alternativeName: Accessory protein 3a alternativeName: Protein 3a alternativeName: Protein U274 alternativeName: Protein X1
displayName	UniProt:P0DTC3 3a
geneName	3a
identifier	P0DTC3
isSequenceChanged	false
keyword	3D-structure Activation of host autophagy by virus Glycoprotein Host cell membrane Host cytoplasm Host endoplasmic reticulum Host endosome Host lysosome Host membrane Host-virus interaction Ion channel Ion transport Membrane Reference proteome Secreted Transmembrane Transmembrane helix Transport Viral ion channel Virion
modified	[InstanceEdit:9917590] Weiser, Joel, 2024-08-09
moleculeType	Protein
name	3a
physicalEntity	[EntityWithAccessionedSequence:R-COV-9694395] O-glycosyl 3a [virion membrane] - Severe acute respiratory syndrome coronavirus 2 [EntityWithAccessionedSequence:R-COV-9694729] O-glycosyl 3a [endocytic vesicle membrane] - Severe acute respiratory syndrome coronavirus 2 [EntityWithAccessionedSequence:R-COV-9694386] O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] - Severe acute respiratory syndrome coronavirus 2 [EntityWithAccessionedSequence:R-COV-9694658] GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] - Severe acute respiratory syndrome coronavirus 2 [EntityWithAccessionedSequence:R-COV-9694716] 3a [endoplasmic reticulum-Golgi intermediate compartment] - Severe acute respiratory syndrome coronavirus 2 [EntityWithAccessionedSequence:R-COV-9694584] 3a [endoplasmic reticulum lumen] - Severe acute respiratory syndrome coronavirus 2 [EntityWithAccessionedSequence:R-COV-9754541] O-glycosyl 3a [endolysosome membrane] - Severe acute respiratory syndrome coronavirus 2 [EntityWithAccessionedSequence:R-COV-9694433] O-glycosyl 3a [plasma membrane] - Severe acute respiratory syndrome coronavirus 2 [EntityWithAccessionedSequence:R-COV-9694387] O-glycosyl 3a [extracellular region] - Severe acute respiratory syndrome coronavirus 2
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12689975] UCSC:P0DTC3 3a
schemaClass	ReferenceGeneProduct
secondaryIdentifier	AP3A_SARS2
sequenceLength	275
species	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
stId	uniprot:P0DTC3
url	http://purl.uniprot.org/uniprot/P0DTC3

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-COV-9694395] O-glycosyl 3a [virion membrane] [EntityWithAccessionedSequence:R-COV-9694729] O-glycosyl 3a [endocytic vesicle membrane] [EntityWithAccessionedSequence:R-COV-9694386] O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] [EntityWithAccessionedSequence:R-COV-9694658] GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] [EntityWithAccessionedSequence:R-COV-9694716] 3a [endoplasmic reticulum-Golgi intermediate compartment] [EntityWithAccessionedSequence:R-COV-9694584] 3a [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-COV-9754541] O-glycosyl 3a [endolysosome membrane] [EntityWithAccessionedSequence:R-COV-9694433] O-glycosyl 3a [plasma membrane] [EntityWithAccessionedSequence:R-COV-9694387] O-glycosyl 3a [extracellular region]
(referenceSequence)	[ModifiedResidue:9694610] O-glycosyl-L-threonine at unknown position [ModifiedResidue:9694328] O-(N-acetylamino)galactosyl-L-threonine at unknown position
(interactor)	[UndirectedInteraction:11174947] UniProt:P0DTC3 <-> UniProt:Q96GS4 (IntAct) [UndirectedInteraction:11174945] UniProt:P0DTC3 <-> UniProt:Q9GZU1 (IntAct) [UndirectedInteraction:11174943] UniProt:P0DTC3 <-> UniProt:Q9H3K2 (IntAct) [UndirectedInteraction:11174941] UniProt:P0DTC3 <-> UniProt:P42765 (IntAct) [UndirectedInteraction:11174939] UniProt:P0DTC3 <-> UniProt:Q8NHV4 (IntAct) [UndirectedInteraction:11174937] UniProt:P0DTC3 <-> UniProt:Q9P253 (IntAct) [UndirectedInteraction:11174935] UniProt:P0DTC3 <-> UniProt:Q9H269 (IntAct) [UndirectedInteraction:11174933] UniProt:P0DTC3 <-> UniProt:Q12913 (IntAct) [UndirectedInteraction:11174931] UniProt:P0DTC3 <-> UniProt:P0DTD1-PRO_0000449632 (IntAct) [UndirectedInteraction:11174927] UniProt:P0DTC3 <-> UniProt:Q8NAF0 (IntAct) [UndirectedInteraction:11174925] UniProt:P0DTC3 <-> UniProt:P0DTD8 (IntAct) [UndirectedInteraction:11174923] UniProt:P0DTC3 <-> UniProt:O75976 (IntAct) [UndirectedInteraction:11174921] UniProt:P0DTC3 <-> UniProt:P30519 (IntAct) [UndirectedInteraction:11174919] UniProt:P0DTC3 <-> UniProt:Q9Y617 (IntAct) [UndirectedInteraction:11174917] UniProt:P0DTC3 <-> UniProt:Q15005 (IntAct) [UndirectedInteraction:11165649] UniProt:P09601 <-> UniProt:P0DTC3 (IntAct) [UndirectedInteraction:11174835] UniProt:P0DTC3 <-> UniProt:Q96JC1 (IntAct) [UndirectedInteraction:11174839] UniProt:P0DTC3 <-> UniProt:Q96S66 (IntAct) [UndirectedInteraction:11174841] UniProt:P0DTC3 <-> UniProt:Q9H270 (IntAct) [UndirectedInteraction:11174843] UniProt:P0DTC3 <-> UniProt:Q9Y673 (IntAct) [UndirectedInteraction:11174845] UniProt:P0DTC3 <-> UniProt:P0DTC3 (IntAct) [UndirectedInteraction:11174845] UniProt:P0DTC3 <-> UniProt:P0DTC3 (IntAct) [UndirectedInteraction:11174847] UniProt:P0DTC3 <-> UniProt:P49754 (IntAct) [UndirectedInteraction:11174849] UniProt:P0DTC3 <-> UniProt:Q9UH99 (IntAct) [UndirectedInteraction:11174851] UniProt:P0DTC3 <-> UniProt:Q8NBJ7 (IntAct) [UndirectedInteraction:11174853] UniProt:P0DTC3 <-> UniProt:Q8N6S5 (IntAct) [UndirectedInteraction:11174857] UniProt:P0DTC3 <-> UniProt:Q8IWR1 (IntAct) [UndirectedInteraction:11174859] UniProt:P0DTC3 <-> UniProt:Q01518 (IntAct) [UndirectedInteraction:11174861] UniProt:P0DTC3 <-> UniProt:Q9P2Y5 (IntAct) [UndirectedInteraction:11174863] UniProt:P0DTC3 <-> UniProt:Q12846 (IntAct) [UndirectedInteraction:11174865] UniProt:P0DTC3 <-> UniProt:P51809 (IntAct) [UndirectedInteraction:11174869] UniProt:P0DTC3 <-> UniProt:P49796-4 (IntAct) [UndirectedInteraction:11174873] UniProt:P0DTC3 <-> UniProt:Q86UT5-2 (IntAct) [UndirectedInteraction:11174875] UniProt:P0DTC3 <-> UniProt:Q5T2W1 (IntAct) [UndirectedInteraction:11174879] UniProt:P0DTC3 <-> UniProt:Q8TEW8 (IntAct) [UndirectedInteraction:11174881] UniProt:P0DTC3 <-> UniProt:Q07157 (IntAct) [UndirectedInteraction:11174883] UniProt:P0DTC3 <-> UniProt:P50454 (IntAct) [UndirectedInteraction:11174885] UniProt:P0DTC3 <-> UniProt:Q8NBS9 (IntAct) [UndirectedInteraction:11174889] UniProt:P0DTC3 <-> UniProt:Q92545 (IntAct) [UndirectedInteraction:11174891] UniProt:P0DTC3 <-> UniProt:Q9H0V9 (IntAct) [UndirectedInteraction:11174893] UniProt:P0DTC3 <-> UniProt:Q96HE7 (IntAct) [UndirectedInteraction:11174895] UniProt:P0DTC3 <-> UniProt:P07205 (IntAct) [UndirectedInteraction:11174897] UniProt:P0DTC3 <-> UniProt:P35609 (IntAct) [UndirectedInteraction:11174899] UniProt:P0DTC3 <-> UniProt:P51153 (IntAct) [UndirectedInteraction:11174903] UniProt:P0DTC3 <-> UniProt:Q9Y4P3 (IntAct) [UndirectedInteraction:11174907] UniProt:P0DTC3 <-> UniProt:Q9NRX4 (IntAct) [UndirectedInteraction:11174909] UniProt:P0DTC3 <-> UniProt:P61106 (IntAct) [UndirectedInteraction:11174911] UniProt:P0DTC3 <-> UniProt:Q9UNN8 (IntAct) [UndirectedInteraction:11174913] UniProt:P0DTC3 <-> UniProt:P04439 (IntAct) [UndirectedInteraction:11174915] UniProt:P0DTC3 <-> UniProt:P16422 (IntAct)

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