UniProt:P0AEU7 skp

chain
  • signal peptide:1-20
  • chain:21-161
checksum 2A966BBD83F3E675
comment
  • FUNCTION Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. Required for the efficient release of OmpA from the inner membrane, the maintenance of its solubility in the periplasm, and, in association with lipopolysaccharide (LPS), for the efficient folding and insertion of OmpA into the outer membrane.SUBUNIT Homotrimer. Interacts with OmpA. Interacts with PhoE during its translocation across the inner membrane, but, in contrast to OmpA, release of PhoE from the inner membrane is not dependent on skp. Also interacts with LamB, OmpC and OmpF.INTERACTION Composed of a compact central beta-barrel domain with long alpha-helical extensions that form a three-pronged structure around an internal cavity. Substrate proteins may be bound in this cavity.MISCELLANEOUS Does not require ATP for its activity.SIMILARITY Belongs to the Skp family.CAUTION Was originally thought to bind DNA. It was probably an artifact due to the cationic nature of skp.
created [InstanceEdit:9927056] Stephan, Ralf, 2024-11-04
crossReference
databaseName UniProt
dbId 9926954
description
  • recommendedName: Chaperone protein Skp alternativeName: DNA-binding 17 kDa protein alternativeName: Histone-like protein HLP-1 alternativeName: Seventeen kilodalton protein
displayName UniProt:P0AEU7 skp
geneName
  • skp
  • hlpA
  • ompH
  • b0178
  • JW0173
identifier P0AEU7
isSequenceChanged false
keyword
  • 3D-structure
  • Chaperone
  • Direct protein sequencing
  • Periplasm
  • Reference proteome
  • Signal
modified [InstanceEdit:9948485] Weiser, Joel, 2025-05-21
moleculeType Protein
name
  • skp
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • SKP_ECOLI
  • P11457
sequenceLength 161
species [Species:159879] Escherichia coli
stId uniprot:P0AEU7
url http://purl.uniprot.org/uniprot/P0AEU7
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