Reactome | UniProt:P0ABZ6 surA

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UniProt:P0ABZ6 surA Show undefined attributes

chain	signal peptide:1-20 chain:21-428
checksum	25F6AD4B903CBD8E
comment	FUNCTION Chaperone involved in the correct folding and assembly of outer membrane proteins, such as OmpA, OmpF and LamB (PubMed:8985185). Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins (PubMed:8985185). May act in both early periplasmic and late outer membrane-associated steps of protein maturation (PubMed:2165476). Essential for the survival of E.coli in stationary phase. Required for pilus biogenesis (PubMed:16267292).CATALYTIC ACTIVITY [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)INTERACTION Is capable of associating with the outer membrane.DOMAIN The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA function as a SurA protein with a deletion of the parvulin domains is almost completely functional in vivo. The N-terminal region and the C-terminal tail are also required for porin recognition.
created	[InstanceEdit:9927056] Stephan, Ralf, 2024-11-04
crossReference	[DatabaseIdentifier:12318340] RefSeq:WP_000800457.1 [DatabaseIdentifier:12318339] RefSeq:NP_414595.1 [DatabaseIdentifier:12243511] PRO:P0ABZ6 [DatabaseIdentifier:12170437] PDB:2PV2 [DatabaseIdentifier:12149576] PDB:9HG9 [DatabaseIdentifier:12149592] PDB:8Q0G [DatabaseIdentifier:12149546] PDB:9HG6 [DatabaseIdentifier:12149557] PDB:8QPU [DatabaseIdentifier:12149563] PDB:8PZV [DatabaseIdentifier:12149548] PDB:9HG5 [DatabaseIdentifier:12149549] PDB:8PZ2 [DatabaseIdentifier:12149551] PDB:8PZ1 [DatabaseIdentifier:12170439] PDB:1M5Y [DatabaseIdentifier:12170438] PDB:2PV1 [DatabaseIdentifier:12149543] PDB:8QP5 [DatabaseIdentifier:12170436] PDB:2PV3 [DatabaseIdentifier:12149568] PDB:9HGA [DatabaseIdentifier:12149558] PDB:8QPV [DatabaseIdentifier:12149607] PDB:8QPW [DatabaseIdentifier:12149544] PDB:9HG7 [DatabaseIdentifier:12149578] PDB:9HG8 [DatabaseIdentifier:12149560] PDB:8PZU
databaseName	UniProt
dbId	9927023
description	recommendedName: Chaperone SurA alternativeName: Peptidyl-prolyl cis-trans isomerase SurA shortName: PPIase SurA ecNumber evidence="5"5.2.1.8 alternativeName: Rotamase SurA alternativeName: Survival protein A
displayName	UniProt:P0ABZ6 surA
geneName	surA b0053 JW0052
identifier	P0ABZ6
isSequenceChanged	false
keyword	3D-structure Chaperone Direct protein sequencing Isomerase Periplasm Reference proteome Repeat Rotamase Signal
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	surA
physicalEntity	[EntityWithAccessionedSequence:R-ECO-9927051] SurA [periplasmic space] - Escherichia coli
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12724237] UCSC:P0ABZ6 surA [ReferenceDNASequence:12028294] NCBI Gene:93777382 surA [ReferenceDNASequence:12028293] NCBI Gene:944812 surA [ReferenceDNASequence:11944201] Monarch:93777382 surA [ReferenceDNASequence:11944200] Monarch:944812 surA [ReferenceDNASequence:11857901] KEGG:ecoc:C3026_00275 surA [ReferenceDNASequence:11857903] KEGG:eco:b0053 surA [ReferenceDNASequence:11857902] KEGG:ecj:JW0052 surA [ReferenceDNASequence:11314411] BioGPS Gene:944812 surA [ReferenceDNASequence:11314412] BioGPS Gene:93777382 surA
referenceTranscript	[ReferenceRNASequence:12487726] RefSeq:NC_000913.3 YDHU [ReferenceRNASequence:12487725] RefSeq:NZ_CP009789.1 YDHU
schemaClass	ReferenceGeneProduct
secondaryIdentifier	SURA_ECOLI P21202 P75630 Q8KIP6 Q8KMY0
sequenceLength	428
species	[Species:159879] Escherichia coli
stId	uniprot:P0ABZ6
url	http://purl.uniprot.org/uniprot/P0ABZ6

Referrals

(referenceEntity)

[EntityWithAccessionedSequence:R-ECO-9927051] SurA [periplasmic space]