Reactome | UniProt:P0A937 bamE

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UniProt:P0A937 bamE Show undefined attributes

chain	signal peptide:1-19 chain:20-113
checksum	CFD8840C014AA0A2
comment	FUNCTION Part of the outer membrane protein assembly complex (Bam), which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Nonessential member of the complex that stabilizes the interaction between the essential proteins BamA and BamD. May modulate the conformation of BamA, likely through interactions with BamD. Efficient substrate folding and insertion into the outer membrane requires all 5 subunits (PubMed:20378773, PubMed:21823654, PubMed:27686148). A lateral gate may open between the first and last strands of the BamA beta-barrel that allows substrate to insert into the outer membrane; comparison of the structures of complete and nearly complete Bam complexes show there is considerable movement of all 5 proteins (PubMed:26744406, PubMed:26900875, PubMed:26901871, PubMed:27686148).SUBUNIT Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE. Forms a subcomplex with BamC and BamD. Monomer in the periplasm, but is able to adopt a dimeric conformation in the cytoplasm (PubMed:21207987). The Bam complex has the shape of a hat, with the BamA beta-barrel crown in the outer membrane and the periplasmic brim formed by the BamA POTRA domains and the 4 lipoproteins (PubMed:26744406, PubMed:26900875, PubMed:26901871, PubMed:27686148). The intact Bam complex can have 2 BamE subunits (PubMed:27686148).INTERACTION With 3 palmitic acid (C16) acyl chains.MASS SPECTROMETRY With 2 palmitic (C16) and 1 stearic (C18) acid acyl chains.DISRUPTION PHENOTYPE Mutants show minor defects in the assembly of outer membrane proteins.SIMILARITY Belongs to the BamE family.SEQUENCE CAUTION Sequence of unknown provenance, it does not match this entry.
created	[InstanceEdit:9927056] Stephan, Ralf, 2024-11-04
crossReference	[DatabaseIdentifier:12149599] PDB:8SQA [DatabaseIdentifier:12308376] RefSeq:NP_417107.2 [DatabaseIdentifier:12308377] RefSeq:WP_001203437.1 [DatabaseIdentifier:12238093] PRO:P0A937 [DatabaseIdentifier:12149597] PDB:6SOH [DatabaseIdentifier:12149592] PDB:8Q0G [DatabaseIdentifier:12149587] PDB:8QN4 [DatabaseIdentifier:12149610] PDB:7RJ5 [DatabaseIdentifier:12149577] PDB:6SN3 [DatabaseIdentifier:12149567] PDB:7RI6 [DatabaseIdentifier:12149553] PDB:7ND0 [DatabaseIdentifier:12149574] PDB:6SN2 [DatabaseIdentifier:12149588] PDB:6SOC [DatabaseIdentifier:12149548] PDB:9HG5 [DatabaseIdentifier:12149559] PDB:8SPR [DatabaseIdentifier:12149601] PDB:7BNQ [DatabaseIdentifier:12149607] PDB:8QPW [DatabaseIdentifier:12149551] PDB:8PZ1 [DatabaseIdentifier:12149565] PDB:6SN9 [DatabaseIdentifier:12149608] PDB:6SO7 [DatabaseIdentifier:12149560] PDB:8PZU [DatabaseIdentifier:12149573] PDB:8BO2 [DatabaseIdentifier:12149603] PDB:6LYR [DatabaseIdentifier:12149596] PDB:9CNX [DatabaseIdentifier:12149590] PDB:6SOB [DatabaseIdentifier:12149546] PDB:9HG6 [DatabaseIdentifier:12149562] PDB:8BWC [DatabaseIdentifier:12149571] PDB:8ADI [DatabaseIdentifier:12149593] PDB:6LYU [DatabaseIdentifier:12149586] PDB:9HE1 [DatabaseIdentifier:12149605] PDB:8SQB [DatabaseIdentifier:12149606] PDB:6LYQ [DatabaseIdentifier:12149600] PDB:9CO0 [DatabaseIdentifier:12149568] PDB:9HGA [DatabaseIdentifier:12149566] PDB:7RI9 [DatabaseIdentifier:12149550] PDB:2KM7 [DatabaseIdentifier:12149547] PDB:6SN0 [DatabaseIdentifier:12149576] PDB:9HG9 [DatabaseIdentifier:12149569] PDB:5AYW [DatabaseIdentifier:12149572] PDB:8ADG [DatabaseIdentifier:12149581] PDB:7RI5 [DatabaseIdentifier:12149570] PDB:7RI7 [DatabaseIdentifier:12149579] PDB:7RI4 [DatabaseIdentifier:12149594] PDB:6SOG [DatabaseIdentifier:12149549] PDB:8PZ2 [DatabaseIdentifier:12149561] PDB:8BNZ [DatabaseIdentifier:12149589] PDB:6LYS [DatabaseIdentifier:12149552] PDB:7TTC [DatabaseIdentifier:12149563] PDB:8PZV [DatabaseIdentifier:12149558] PDB:8QPV [DatabaseIdentifier:12149598] PDB:9CNY [DatabaseIdentifier:12149575] PDB:6SN4 [DatabaseIdentifier:12149527] PDB:2YH9 [DatabaseIdentifier:12149545] PDB:5LJO [DatabaseIdentifier:12149535] PDB:5D0Q [DatabaseIdentifier:12149543] PDB:8QP5 [DatabaseIdentifier:12149539] PDB:5EKQ [DatabaseIdentifier:12149533] PDB:7TT3 [DatabaseIdentifier:12149537] PDB:7YE4 [DatabaseIdentifier:12149531] PDB:7TT5 [DatabaseIdentifier:12149544] PDB:9HG7 [DatabaseIdentifier:12149530] PDB:7TT0 [DatabaseIdentifier:12149528] PDB:7TT1 [DatabaseIdentifier:12149536] PDB:7YE6 [DatabaseIdentifier:12149534] PDB:7TT4 [DatabaseIdentifier:12149542] PDB:7R1W [DatabaseIdentifier:12149532] PDB:7TT6 [DatabaseIdentifier:12149541] PDB:7NBX [DatabaseIdentifier:12149538] PDB:2KXX [DatabaseIdentifier:12149540] PDB:5D0O [DatabaseIdentifier:12149529] PDB:7TT2 [DatabaseIdentifier:12149584] PDB:8BVQ [DatabaseIdentifier:12149583] PDB:6SN7 [DatabaseIdentifier:12149585] PDB:6SOJ [DatabaseIdentifier:12149609] PDB:6V05 [DatabaseIdentifier:12149591] PDB:9CNW [DatabaseIdentifier:12149611] PDB:6SO8 [DatabaseIdentifier:12149555] PDB:7NCS [DatabaseIdentifier:12149595] PDB:9CNZ [DatabaseIdentifier:12149557] PDB:8QPU [DatabaseIdentifier:12149602] PDB:7NRI [DatabaseIdentifier:12149556] PDB:7TSZ [DatabaseIdentifier:12149582] PDB:6SN8 [DatabaseIdentifier:12149578] PDB:9HG8 [DatabaseIdentifier:12149554] PDB:7TT7 [DatabaseIdentifier:12149580] PDB:6SN5 [DatabaseIdentifier:12149564] PDB:6SMX [DatabaseIdentifier:12149604] PDB:6SOA
databaseName	UniProt
dbId	9926968
description	recommendedName: fullName evidence="1"Outer membrane protein assembly factor BamE
displayName	UniProt:P0A937 bamE
geneName	bamE smpA b2617 JW2598
identifier	P0A937
isSequenceChanged	false
keyword	3D-structure Cell outer membrane Lipoprotein Membrane Palmitate Reference proteome Signal
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	bamE
physicalEntity	[EntityWithAccessionedSequence:R-ECO-9927008] BamE [cell outer membrane] - Escherichia coli
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11309788] BioGPS Gene:93774466 bamE [ReferenceDNASequence:12721535] UCSC:P0A937 bamE [ReferenceDNASequence:11309789] BioGPS Gene:945583 bamE [ReferenceDNASequence:11853516] KEGG:eco:b2617 bamE [ReferenceDNASequence:11853515] KEGG:ecoc:C3026_14485 bamE [ReferenceDNASequence:11853514] KEGG:ecj:JW2598 bamE [ReferenceDNASequence:11939577] Monarch:93774466 bamE [ReferenceDNASequence:11939578] Monarch:945583 bamE [ReferenceDNASequence:12023671] NCBI Gene:945583 bamE [ReferenceDNASequence:12023670] NCBI Gene:93774466 bamE
referenceTranscript	[ReferenceRNASequence:12487726] RefSeq:NC_000913.3 YDHU [ReferenceRNASequence:12487725] RefSeq:NZ_CP009789.1 YDHU
schemaClass	ReferenceGeneProduct
secondaryIdentifier	BAME_ECOLI P23089
sequenceLength	113
species	[Species:159879] Escherichia coli
stId	uniprot:P0A937
url	http://purl.uniprot.org/uniprot/P0A937

Referrals

(referenceEntity)

[EntityWithAccessionedSequence:R-ECO-9927008] BamE [cell outer membrane]

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