Reactome | UniProt:P09038 FGF2

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UniProt:P09038 FGF2 Show undefined attributes

chain	propeptide:1-142 chain:143-288
checksum	EAE98552A39D5E19
comment	FUNCTION Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:28302677, PubMed:8663044). Functions as a potent mitogen in vitro (PubMed:1721615, PubMed:3732516, PubMed:3964259). Can induce angiogenesis (PubMed:23469107, PubMed:28302677). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (PubMed:29501879).BIOPHYSICOCHEMICAL PROPERTIES Retains almost half of its activity after treatment at pH 2.0 for 3 hours at 20 degrees Celsius.SUBUNIT Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP3 (PubMed:18669637). Interacts with integrin ITGAV:ITGB3; the interaction is required for FGF2 signaling (PubMed:28302677). Interacts with SNORC (via the extracellular domain) (By similarity). Interacts with glypican GPC3 (By similarity).INTERACTION Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (PubMed:20230531). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol (PubMed:22321063). Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (PubMed:22321063).ALTERNATIVE PRODUCTS Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.PTM Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.PTM Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing.MISCELLANEOUS This protein binds heparin more strongly than does aFGF.MISCELLANEOUS Starts at an alternative CUG codon.MISCELLANEOUS Starts at an alternative CUG codon.MISCELLANEOUS Starts at an alternative CUG codon.SIMILARITY Belongs to the heparin-binding growth factors family.SEQUENCE CAUTION Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.SEQUENCE CAUTION Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.SEQUENCE CAUTION Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.
crossReference	[DatabaseIdentifier:12184604] PDB:8OM6 [DatabaseIdentifier:12816711] ZINC target:P09038 [DatabaseIdentifier:12813308] ZINC - Substances:FGF2_HUMAN [DatabaseIdentifier:12809220] ZINC - Predictions - Purchasable:FGF2_HUMAN [DatabaseIdentifier:12323084] RefSeq:NP_001348594.1 [DatabaseIdentifier:12323085] RefSeq:NP_001997.5 [DatabaseIdentifier:12286193] Pharos - Targets:P09038 [DatabaseIdentifier:12245981] PRO:P09038 [DatabaseIdentifier:12184590] PDB:2FGF [DatabaseIdentifier:12184596] PDB:1FQ9 [DatabaseIdentifier:12184594] PDB:1BFF [DatabaseIdentifier:12175960] PDB:6L4O [DatabaseIdentifier:12184593] PDB:4OEG [DatabaseIdentifier:12184599] PDB:2M49 [DatabaseIdentifier:12184601] PDB:1BFC [DatabaseIdentifier:12184598] PDB:1BAS [DatabaseIdentifier:12184595] PDB:4FGF [DatabaseIdentifier:12184591] PDB:4OEF [DatabaseIdentifier:12184589] PDB:4OEE [DatabaseIdentifier:11451435] ENSEMBL:ENSG00000138685 [DatabaseIdentifier:11540863] ENSEMBL:ENSP00000264498 [DatabaseIdentifier:11540864] ENSEMBL:ENSP00000477134 [DatabaseIdentifier:11540862] ENSEMBL:ENSP00000494222 [DatabaseIdentifier:11663561] ENSEMBL:ENST00000608478 [DatabaseIdentifier:11663563] ENSEMBL:ENST00000644866 [DatabaseIdentifier:11663562] ENSEMBL:ENST00000264498 [DatabaseIdentifier:11788302] GeneCards:FGF2 [DatabaseIdentifier:11832924] HMDB Protein:HMDBP02107 [DatabaseIdentifier:11841356] HPA:ENSG00000138685-FGF2 [DatabaseIdentifier:12125921] OpenTargets:ENSG00000138685 [DatabaseIdentifier:12184582] PDB:2BFH [DatabaseIdentifier:12184587] PDB:1FGA [DatabaseIdentifier:12184585] PDB:1IIL [DatabaseIdentifier:12184584] PDB:8HU7 [DatabaseIdentifier:12184588] PDB:5X1O [DatabaseIdentifier:12184586] PDB:1II4 [DatabaseIdentifier:12184583] PDB:1EV2 [DatabaseIdentifier:12184603] PDB:8HUE [DatabaseIdentifier:12184597] PDB:1BLA [DatabaseIdentifier:12184605] PDB:1BLD [DatabaseIdentifier:12184592] PDB:1BFG [DatabaseIdentifier:12184602] PDB:1BFB [DatabaseIdentifier:12184600] PDB:1CVS
databaseName	UniProt
dbId	54764
description	recommendedName: Fibroblast growth factor 2 shortName: FGF-2 alternativeName: Basic fibroblast growth factor shortName: bFGF alternativeName: Heparin-binding growth factor 2 shortName: HBGF-2
displayName	UniProt:P09038 FGF2
geneName	FGF2 FGFB
identifier	P09038
isSequenceChanged	false
keyword	3D-structure Alternative initiation Angiogenesis Developmental protein Differentiation Direct protein sequencing Growth factor Heparin-binding Isopeptide bond Methylation Mitogen Nucleus Phosphoprotein Proteomics identification Reference proteome Secreted Ubl conjugation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	FGF2
otherIdentifier	11725039_at 11725040_at 11725041_at 1593_at 16970404 1828_s_at 204421_PM_s_at 204421_s_at 204422_PM_s_at 204422_s_at 2247 2742110 2742111 2742112 2742113 2742114 2742121 2742125 2742126 2742127 2742128 2742129 41806_at 8097256 A_14_P107501 A_14_P108631 A_23_P218918 A_33_P3379886 A_33_P3419696 GE57510 GO:0001525 GO:0001649 GO:0001658 GO:0001759 GO:0001935 GO:0001938 GO:0002042 GO:0002052 GO:0005104 GO:0005125 GO:0005178 GO:0005515 GO:0005576 GO:0005615 GO:0005634 GO:0005737 GO:0006325 GO:0006351 GO:0006355 GO:0006366 GO:0006935 GO:0007165 GO:0007265 GO:0007399 GO:0007405 GO:0008083 GO:0008201 GO:0008283 GO:0008284 GO:0008285 GO:0008543 GO:0009792 GO:0009887 GO:0010001 GO:0010595 GO:0010628 GO:0010629 GO:0010764 GO:0014843 GO:0019956 GO:0021762 GO:0021930 GO:0021940 GO:0022008 GO:0030154 GO:0030214 GO:0030324 GO:0030334 GO:0038001 GO:0040037 GO:0042056 GO:0042060 GO:0042491 GO:0042660 GO:0042802 GO:0043406 GO:0043410 GO:0043491 GO:0043536 GO:0043537 GO:0043542 GO:0045471 GO:0045609 GO:0045669 GO:0045765 GO:0045766 GO:0045944 GO:0046668 GO:0048018 GO:0048149 GO:0048598 GO:0048661 GO:0048678 GO:0048856 GO:0048863 GO:0048864 GO:0048870 GO:0050673 GO:0050679 GO:0050918 GO:0051209 GO:0051726 GO:0051781 GO:0051897 GO:0055085 GO:0060045 GO:0060070 GO:0060128 GO:0060129 GO:0060563 GO:0060591 GO:0060644 GO:0060978 GO:0061045 GO:0062072 GO:0070371 GO:0070374 GO:0071260 GO:0072089 GO:0090049 GO:0090050 GO:0090263 GO:0090722 GO:0098772 GO:1901135 GO:1902748 GO:1902895 GO:1902913 GO:1903377 GO:1903587 GO:1903672 GO:1904567 GO:1904707 GO:1904977 GO:1905278 GO:1905330 GO:1905555 GO:1905564 GO:2000544 GO:2000546 GO:2000573 GO:2000647 GO:2000648 GO:2000738 GO:2001028 HMNXSV003036302 ILMN_1744693 ILMN_2105919 J04513_at M27968_s_at PH_hs_0028108 TC04000630.hg TC04002187.hg g182562_3p_s_at g4503698_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-189898] FGF2(143-288) [extracellular region] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000138685] ENSEMBL:ENSG00000138685 FGF2 [ReferenceDNASequence:12725783] UCSC:P09038 FGF2 [ReferenceDNASequence:11316798] BioGPS Gene:2247 FGF2 [ReferenceDNASequence:11397903] COSMIC - genes:FGF2 FGF2 [ReferenceDNASequence:11414476] CTD Gene:2247 FGF2 [ReferenceDNASequence:11434662] dbSNP Gene:2247 FGF2 [ReferenceDNASequence:11819954] HGNC:3676 FGF2 [ReferenceDNASequence:11860053] KEGG:hsa:2247 FGF2 [ReferenceDNASequence:11946587] Monarch:2247 FGF2 [ReferenceDNASequence:12030680] NCBI Gene:2247 FGF2 [ReferenceDNASequence:12111091] OMIM:134920 FGF2
referenceTranscript	[ReferenceRNASequence:12505057] RefSeq:NM_001361665.2 FGF2 [ReferenceRNASequence:12505056] RefSeq:NM_002006.4 FGF2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	FGF2_HUMAN A4LBB8 O00527 P78443 Q16443 Q5PY50 Q7KZ11 Q7KZ72 Q9UC54 Q9UCS5 Q9UCS6
sequenceLength	288
species	[Species:48887] Homo sapiens
stId	uniprot:P09038
url	http://purl.uniprot.org/uniprot/P09038

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[EntityWithAccessionedSequence:R-HSA-189898] FGF2(143-288) [extracellular region]

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