UniProt:P00748 F12

chain
  • signal peptide:1-19
  • chain:20-372
  • chain:354-362
  • chain:373-615
checksum F5B861BF635EB480
comment
  • FUNCTION Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (PubMed:2019570, PubMed:21304106, PubMed:8427954).CATALYTIC ACTIVITY Selective cleavage of Arg-|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.ACTIVITY REGULATION Activity is promoted in the presence of negatively charged surfaces.SUBUNIT Interacts with HRG; the interaction, which is enhanced in the presence of zinc ions and inhibited by heparin-binding, inhibits factor XII autoactivation and contact-initiated coagulation.(PubMed:21304106) Interacts (inactive and activated) with D7L2, an anticoagulant protein from Anopheles gambiae (PubMed:35460690). Interacts (activated) with iripin-8, a serine protease inhibitor from Ixodes ricinus saliva (PubMed:34502392). Interacts (inactive and activated) (via amino acids 1-77) with triafestin-1 and triafestin-2, anticoagulant proteins from Triatoma infestans (PubMed:17645545). Interacts (inactive and activated) (via amino acids 1-77) with short form salivary protein D7R1, an anticoagulant protein from Anopheles stephensi (PubMed:17645545). Interacts (inactive and activated) (via fibronectin type II domain) with haemaphysalin, an anticoagulant protein from Haemaphysalis longicornis (PubMed:15711755, PubMed:16169873).INTERACTION Factor XII is activated by kallikrein in alpha-factor XIIa, which is further converted by trypsin into beta-factor XIIa. Alpha-factor XIIa is composed of an NH2-terminal heavy chain, called coagulation factor XIIa heavy chain, and a COOH-terminal light chain, called coagulation factor XIIa light chain, connected by a disulfide bond. Beta-factor XIIa is composed of 2 chains linked by a disulfide bond, an N-terminal nonapeptide, called beta-factor XIIa part 1, and coagulation factor XIIa light chain, also known in this context as beta-factor XIIa part 2.PTM O- and N-glycosylated. The O-linked polysaccharides were not identified, but are probably the mucin type linked to GalNAc.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the peptidase S1 family.ONLINE INFORMATION Factor XII entry
crossReference
databaseName UniProt
dbId 54586
description
  • recommendedName: Coagulation factor XII ecNumber evidence="20 33"3.4.21.38 alternativeName: Hageman factor shortName: HAF component recommendedName: Coagulation factor XIIa heavy chain /component component recommendedName: Beta-factor XIIa part 1 /component component recommendedName: Coagulation factor XIIa light chain alternativeName: Beta-factor XIIa part 2 /component
displayName UniProt:P00748 F12
geneName
  • F12
identifier P00748
isSequenceChanged false
keyword
  • 3D-structure
  • Blood coagulation
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • EGF-like domain
  • Fibrinolysis
  • Glycoprotein
  • Hemostasis
  • Hydrolase
  • Kringle
  • Protease
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Secreted
  • Serine protease
  • Signal
  • Zymogen
modified [InstanceEdit:9948485] Weiser, Joel, 2025-05-21
moleculeType Protein
name
  • F12
otherIdentifier
  • 11733764_at
  • 11756323_x_at
  • 17003224
  • 17003228
  • 205774_PM_at
  • 205774_at
  • 215961_PM_at
  • 215961_at
  • 2161
  • 2888736
  • 2888738
  • 2888740
  • 2888742
  • 2888743
  • 2888744
  • 2888745
  • 2888746
  • 2888747
  • 2888748
  • 2888749
  • 2888750
  • 2888751
  • 2888752
  • 2888753
  • 2888754
  • 2888755
  • 2888756
  • 2888757
  • 2888758
  • 2888759
  • 2888760
  • 2888761
  • 2888762
  • 2888763
  • 2888764
  • 2888765
  • 2888766
  • 2888767
  • 2888768
  • 2888769
  • 2888770
  • 2888771
  • 2888772
  • 37838_at
  • 8116031
  • 8116033
  • A_23_P167674
  • A_24_P49997
  • A_33_P3233871
  • GE57922
  • GO:0002353
  • GO:0002376
  • GO:0002542
  • GO:0004252
  • GO:0005509
  • GO:0005515
  • GO:0005576
  • GO:0005615
  • GO:0005783
  • GO:0005791
  • GO:0005886
  • GO:0006508
  • GO:0007596
  • GO:0007597
  • GO:0007599
  • GO:0008233
  • GO:0008236
  • GO:0010756
  • GO:0016485
  • GO:0016540
  • GO:0016787
  • GO:0030194
  • GO:0030312
  • GO:0031012
  • GO:0031638
  • GO:0042730
  • GO:0045087
  • GO:0051604
  • GO:0051787
  • GO:0051788
  • GO:0051919
  • GO:0070062
  • GO:0098542
  • HMNXSV003050126
  • HMNXSV003051677
  • Hs.1321.1.S1_3p_at
  • ILMN_1671766
  • ILMN_1718018
  • M17466_at
  • PH_hs_0000179
  • PH_hs_0031702
  • TC05002104.hg
  • TC05002105.hg
  • g9961354_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • FA12_HUMAN
  • P78339
sequenceLength 615
species [Species:48887] Homo sapiens
stId uniprot:P00748
url http://purl.uniprot.org/uniprot/P00748

Referrals

(referenceEntity)
(referenceSequence)
(interactor)
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