Reactome | UniProt:O15178 TBXT

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UniProt:O15178 TBXT Show undefined attributes

chain	chain:1-435
checksum	9D470088C8602631
comment	FUNCTION Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence and activates gene transcription when bound to such a site.SUBUNIT Monomer.SUBCELLULAR LOCATION Detected in testis, but not in other, normal tissues. Detected in lung tumors (at protein level).DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication.DISEASE The disease is caused by variants affecting the gene represented in this entry.
crossReference	[DatabaseIdentifier:12171672] PDB:5QSH [DatabaseIdentifier:12363337] RefSeq:NP_003172.1 [DatabaseIdentifier:12363336] RefSeq:XP_047275225.1 [DatabaseIdentifier:12363338] RefSeq:NP_001257413.1 [DatabaseIdentifier:12284524] Pharos - Targets:O15178 [DatabaseIdentifier:12263099] PRO:O15178 [DatabaseIdentifier:12171714] PDB:5QRG [DatabaseIdentifier:12171723] PDB:5QRL [DatabaseIdentifier:12171711] PDB:5QS6 [DatabaseIdentifier:12171719] PDB:5QRK [DatabaseIdentifier:12171706] PDB:5QRS [DatabaseIdentifier:12171718] PDB:5QRH [DatabaseIdentifier:12171710] PDB:5QRU [DatabaseIdentifier:12171722] PDB:5QRM [DatabaseIdentifier:12171712] PDB:5QRT [DatabaseIdentifier:12171725] PDB:6ZU8 [DatabaseIdentifier:12171717] PDB:6F58 [DatabaseIdentifier:12171707] PDB:5QS4 [DatabaseIdentifier:12171709] PDB:5QS3 [DatabaseIdentifier:12171724] PDB:8A10 [DatabaseIdentifier:12171715] PDB:5QRF [DatabaseIdentifier:12171713] PDB:5QS5 [DatabaseIdentifier:12171716] PDB:5QRI [DatabaseIdentifier:12171705] PDB:5QS1 [DatabaseIdentifier:12171721] PDB:6F59 [DatabaseIdentifier:12171708] PDB:5QRR [DatabaseIdentifier:12171720] PDB:5QRJ [DatabaseIdentifier:12171680] PDB:5QSA [DatabaseIdentifier:12171671] PDB:7ZKF [DatabaseIdentifier:12171684] PDB:5QSE [DatabaseIdentifier:12171686] PDB:5QS8 [DatabaseIdentifier:12171693] PDB:8FMU [DatabaseIdentifier:12171687] PDB:5QRV [DatabaseIdentifier:12171679] PDB:5QSB [DatabaseIdentifier:12171692] PDB:5QRZ [DatabaseIdentifier:12171677] PDB:5QSK [DatabaseIdentifier:11470351] ENSEMBL:ENSG00000164458 [DatabaseIdentifier:11567146] ENSEMBL:ENSP00000296946 [DatabaseIdentifier:11567147] ENSEMBL:ENSP00000355836 [DatabaseIdentifier:11689845] ENSEMBL:ENST00000366871 [DatabaseIdentifier:11689846] ENSEMBL:ENST00000296946 [DatabaseIdentifier:11786607] GeneCards:TBXT [DatabaseIdentifier:11802090] GlyGen:O15178 [DatabaseIdentifier:11839684] HPA:ENSG00000164458-TBXT [DatabaseIdentifier:12124210] OpenTargets:ENSG00000164458 [DatabaseIdentifier:12171698] PDB:7HI9 [DatabaseIdentifier:12171689] PDB:5QRY [DatabaseIdentifier:12171700] PDB:5QS0 [DatabaseIdentifier:12171694] PDB:7ZL2 [DatabaseIdentifier:12171699] PDB:5QRO [DatabaseIdentifier:12171704] PDB:5QRP [DatabaseIdentifier:12171670] PDB:5QT0 [DatabaseIdentifier:12171691] PDB:5QS9 [DatabaseIdentifier:12171681] PDB:5QSD [DatabaseIdentifier:12171683] PDB:5QSF [DatabaseIdentifier:12171702] PDB:5QRQ [DatabaseIdentifier:12171685] PDB:5QRW [DatabaseIdentifier:12171682] PDB:5QSC [DatabaseIdentifier:12171688] PDB:5QS7 [DatabaseIdentifier:12171701] PDB:5QRN [DatabaseIdentifier:12171695] PDB:8CDN [DatabaseIdentifier:12171690] PDB:5QRX [DatabaseIdentifier:12171673] PDB:5QSG [DatabaseIdentifier:12171703] PDB:5QS2 [DatabaseIdentifier:12171678] PDB:7ZK2 [DatabaseIdentifier:12171696] PDB:7HI8 [DatabaseIdentifier:12171674] PDB:5QSJ [DatabaseIdentifier:12171697] PDB:8A7N [DatabaseIdentifier:12171675] PDB:5QSI [DatabaseIdentifier:12171676] PDB:5QSL
databaseName	UniProt
dbId	50944
description	recommendedName: fullName evidence="11"T-box transcription factor T alternativeName: fullName evidence="11"Brachyury protein alternativeName: Protein T
displayName	UniProt:O15178 TBXT
geneName	TBXT T
identifier	O15178
isSequenceChanged	false
keyword	3D-structure Activator Alternative splicing Developmental protein Disease variant DNA-binding Nucleus Proteomics identification Reference proteome Transcription Transcription regulation
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	TBXT
otherIdentifier	11740136_a_at 17025576 206524_PM_at 206524_at 2984501 2984502 2984503 2984505 2984506 2984507 2984508 2984509 2984510 2984511 2984513 2984514 2984515 2984516 2984517 2984518 34966_at 6862 8130703 A_24_P63642 A_33_P3709150 GE87897 GO:0000122 GO:0000785 GO:0000978 GO:0000981 GO:0001570 GO:0001707 GO:0001708 GO:0001756 GO:0001839 GO:0001843 GO:0003007 GO:0003677 GO:0003700 GO:0003714 GO:0005634 GO:0005654 GO:0005737 GO:0006351 GO:0006355 GO:0006357 GO:0006366 GO:0007165 GO:0007341 GO:0007498 GO:0007509 GO:0008283 GO:0008284 GO:0008595 GO:0009653 GO:0009952 GO:0014028 GO:0022414 GO:0023019 GO:0030154 GO:0030903 GO:0036342 GO:0043565 GO:0045893 GO:0045944 GO:0048706 GO:0048856 GO:0048870 GO:0060349 GO:0060379 GO:0061371 GO:0061629 GO:0071300 GO:0090009 GO:1990837 HMNXSV003005767 HMNXSV003043729 ILMN_1794551 ILMN_2120762 PH_hs_0024502 TC06002304.hg g4507338_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-452976] TBXT [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000164458] ENSEMBL:ENSG00000164458 TBXT [ReferenceDNASequence:12737230] UCSC:O15178 TBXT [ReferenceDNASequence:11335310] BioGPS Gene:6862 TBXT [ReferenceDNASequence:11399176] COSMIC - genes:TBXT TBXT [ReferenceDNASequence:11411778] CTD Gene:6862 TBXT [ReferenceDNASequence:11436128] dbSNP Gene:6862 TBXT [ReferenceDNASequence:11818244] HGNC:11515 TBXT [ReferenceDNASequence:11876523] KEGG:hsa:6862 TBXT [ReferenceDNASequence:11965099] Monarch:6862 TBXT [ReferenceDNASequence:12049192] NCBI Gene:6862 TBXT [ReferenceDNASequence:12109641] OMIM:601397 TBXT
referenceTranscript	[ReferenceRNASequence:12545170] RefSeq:NM_003181.4 TBXT [ReferenceRNASequence:12545169] RefSeq:XM_047419269.1 TBXT [ReferenceRNASequence:12545168] RefSeq:NM_001270484.2 TBXT
schemaClass	ReferenceGeneProduct
secondaryIdentifier	TBXT_HUMAN E7ERD6 Q4KMP4
sequenceLength	435
species	[Species:48887] Homo sapiens
stId	uniprot:O15178
url	http://purl.uniprot.org/uniprot/O15178

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-452976] TBXT [nucleoplasm]
(interactor)	[UndirectedInteraction:11217463] UniProt:Q12857 <-> UniProt:O15178 (IntAct) [UndirectedInteraction:11261859] UniProt:O15178 <-> UniProt:O00712 (IntAct)

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