Reactome | KDM1A [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-XTR-5625850] p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] - Xenopus tropicalis [Complex:R-XTR-4657016] BHC complex [nucleoplasm] - Xenopus tropicalis [Complex:R-XTR-4657015] CoREST complex [nucleoplasm] - Xenopus tropicalis
consumedByEvent	[Reaction:R-XTR-5625849] Demethylase KDM1A binds KLK2 and KLK3 promoters - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10680410
displayName	KDM1A [nucleoplasm]
endCoordinate	852
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-996769] KDM1A [nucleoplasm] - Homo sapiens
maxDepth	1
name	KDM1A F6ZUK1
producedByEvent	[Reaction:R-XTR-5625870] KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters - Xenopus tropicalis
referenceEntity	[ReferenceGeneProduct:uniprot:F6ZUK1] UniProt:F6ZUK1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-996769
startCoordinate	1

(hasComponent)	[Complex:R-XTR-4657016] BHC complex [nucleoplasm] [Complex:R-XTR-5625850] p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] [Complex:R-XTR-5625863] p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1A [nucleoplasm] [Complex:R-XTR-4657015] CoREST complex [nucleoplasm]
(output)	[Reaction:R-XTR-5625870] KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters
(activeUnit)	[CatalystActivity:10699599] histone demethylase activity of p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1A [nucleoplasm] [CatalystActivity:10699588] histone demethylase activity of p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm]
(input)	[Reaction:R-XTR-5625849] Demethylase KDM1A binds KLK2 and KLK3 promoters
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-996769] KDM1A [nucleoplasm]