Reactome | C3 binds C3 inhibitors

Schema > Reaction > Entries

category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10728174
displayName	C3 binds C3 inhibitors
eventOf	[Pathway:R-XTR-174577] Activation of C3 and C5 - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9957021] C3 binds C3 inhibitors - Homo sapiens
input	[CandidateSet:R-ALL-9957061] C3 inhibitors [extracellular region] [Complex:R-XTR-166822] Complement factor 3 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	C3 binds C3 inhibitors
output	[Complex:R-XTR-9957071] C3:C3 inhibitors [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9957021
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-XTR-174577] Activation of C3 and C5
(inferredTo)	[Reaction:R-HSA-9957021] C3 binds C3 inhibitors

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