Reactome | C3 binds C3 inhibitors

Schema > Reaction > Entries

C3 binds C3 inhibitors Show undefined attributes

authored	[InstanceEdit:9853559] Shamovsky, Veronica, 2023-11-17
category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9957047] Shamovsky, Veronica, 2025-06-17
dbId	9957021
displayName	C3 binds C3 inhibitors
edited	[InstanceEdit:9963520] Shamovsky, Veronica, 2025-08-14
eventOf	[Pathway:R-HSA-174577] Activation of C3 and C5 - Homo sapiens
input	[CandidateSet:R-ALL-9957061] C3 inhibitors [extracellular region] [Complex:R-HSA-166822] Complement factor 3 [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9957039] Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors [LiteratureReference:9957015] From discovery to approval: A brief history of the compstatin family of complement C3 inhibitors
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	C3 binds C3 inhibitors
orthologousEvent	[Reaction:R-GGA-9957021] C3 binds C3 inhibitors - Gallus gallus [Reaction:R-XTR-9957021] C3 binds C3 inhibitors - Xenopus tropicalis [Reaction:R-DRE-9957021] C3 binds C3 inhibitors - Danio rerio [Reaction:R-SSC-9957021] C3 binds C3 inhibitors - Sus scrofa [Reaction:R-BTA-9957021] C3 binds C3 inhibitors - Bos taurus [Reaction:R-CFA-9957021] C3 binds C3 inhibitors - Canis familiaris [Reaction:R-RNO-9957021] C3 binds C3 inhibitors - Rattus norvegicus [Reaction:R-MMU-9957021] C3 binds C3 inhibitors - Mus musculus
output	[Complex:R-HSA-9957071] C3:C3 inhibitors [extracellular region]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9961904] Duan, Huiquan, 2025-07-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9957021
summation	[Summation:9957044] Uncontrolled activation of the complement system significant...

Referrals

(hasEvent)

[Pathway:R-HSA-174577] Activation of C3 and C5