Reactome | GBP1:GTP binds LPS on the bacterial surface

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GBP1:GTP binds LPS on the bacterial surface Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:25409] peptidoglycan-based cell wall
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10727925
displayName	GBP1:GTP binds LPS on the bacterial surface
eventOf	[Pathway:R-XTR-9953170] GBP-mediated host defense - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:260754] detection of lipopolysaccharide
inferredFrom	[Reaction:R-HSA-9947932] GBP1:GTP binds LPS on the bacterial surface - Homo sapiens
input	[SimpleEntity:R-ALL-6803081] LPS [peptidoglycan-based cell wall] 2 × [Complex:R-XTR-9947884] S-farn-GBP1:GTP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GBP1:GTP binds LPS on the bacterial surface
output	[Complex:R-XTR-9947917] S-farn-GBP1:GTP:LPS [peptidoglycan-based cell wall]
precedingEvent	[Reaction:R-XTR-9968553] GBP1 binds GTP - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9947932
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9953170] GBP-mediated host defense
(inferredTo)	[Reaction:R-HSA-9947932] GBP1:GTP binds LPS on the bacterial surface

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