Reactome | GBP1:GTP binds LPS on the bacterial surface

Schema > Reaction > Entries

GBP1:GTP binds LPS on the bacterial surface Show undefined attributes

authored	[InstanceEdit:9963520] Shamovsky, Veronica, 2025-08-14
category	binding
compartment	[Compartment:70101] cytosol [Compartment:25409] peptidoglycan-based cell wall
created	[InstanceEdit:9947847] Shamovsky, Veronica, 2025-05-14
dbId	9947932
displayName	GBP1:GTP binds LPS on the bacterial surface
edited	[InstanceEdit:9970963] Shamovsky, Veronica, 2025-11-03
entityOnOtherCell	[SimpleEntity:R-ALL-6803081] LPS [peptidoglycan-based cell wall]
eventOf	[Pathway:R-HSA-9953170] GBP-mediated host defense - Homo sapiens
followingEvent	[Polymerisation:R-HSA-9947842] GBP1 hydrolyzes GTP forming GBP1 oligomers - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:260754] detection of lipopolysaccharide
input	[SimpleEntity:R-ALL-6803081] LPS [peptidoglycan-based cell wall] 2 × [Complex:R-HSA-9947884] S-farn-GBP1:GTP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9947834] Nucleotide-dependent farnesyl switch orchestrates polymerization and membrane binding of human guanylate-binding protein 1 [LiteratureReference:9947892] Structural basis of antimicrobial membrane coat assembly by human GBP1 [LiteratureReference:9947890] Structural insights into the activation mechanism of antimicrobial GBP1 [LiteratureReference:9947832] Structural requirements for membrane binding of human guanylate-binding protein 1 [LiteratureReference:9947948] Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria [LiteratureReference:9947909] Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	GBP1:GTP binds LPS on the bacterial surface
orthologousEvent	[Reaction:R-DDI-9947932] GBP1:GTP binds LPS on the bacterial surface - Dictyostelium discoideum [Reaction:R-GGA-9947932] GBP1:GTP binds LPS on the bacterial surface - Gallus gallus [Reaction:R-XTR-9947932] GBP1:GTP binds LPS on the bacterial surface - Xenopus tropicalis [Reaction:R-DRE-9947932] GBP1:GTP binds LPS on the bacterial surface - Danio rerio [Reaction:R-SSC-9947932] GBP1:GTP binds LPS on the bacterial surface - Sus scrofa [Reaction:R-BTA-9947932] GBP1:GTP binds LPS on the bacterial surface - Bos taurus [Reaction:R-CFA-9947932] GBP1:GTP binds LPS on the bacterial surface - Canis familiaris [Reaction:R-RNO-9947932] GBP1:GTP binds LPS on the bacterial surface - Rattus norvegicus
output	[Complex:R-HSA-9947917] S-farn-GBP1:GTP:LPS [peptidoglycan-based cell wall]
precedingEvent	[Reaction:R-HSA-9968553] GBP1 binds GTP - Homo sapiens
releaseDate	2025-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9970618] Daumke, Oliver, 2025-10-31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9947932
summation	[Summation:9947871] Guanylate-binding protein 1 (GBP1) localizes to the lipopoly...

Referrals

(hasEvent)	[Pathway:R-HSA-9953170] GBP-mediated host defense
(precedingEvent)	[Polymerisation:R-HSA-9947842] GBP1 hydrolyzes GTP forming GBP1 oligomers