Reactome | PDH E1 decarboxylates PYR, transferring acetyl to DLAT

Schema > Reaction > Entries

PDH E1 decarboxylates PYR, transferring acetyl to DLAT Show undefined attributes

catalystActivity	[CatalystActivity:10726438] pyruvate dehydrogenase (acetyl-transferring) activity of PDH complex [mitochondrial matrix]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10726440
displayName	PDH E1 decarboxylates PYR, transferring acetyl to DLAT
eventOf	[Pathway:R-XTR-9861559] PDH complex synthesizes acetyl-CoA from PYR - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-9861667] DLAT trimer transfers acetyl to CoA - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-9861734] PDH E1 decarboxylates PYR, transferring acetyl to DLAT - Homo sapiens
input	[EntityWithAccessionedSequence:R-XTR-69969] dlat [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113557] PYR [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	PDH E1 decarboxylates PYR, transferring acetyl to DLAT
output	[SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [EntityWithAccessionedSequence:R-XTR-9861594] dlat [mitochondrial matrix]
precedingEvent	[Reaction:R-XTR-204169] PDP1,2 dephosphorylate p-lipo-PDH - Xenopus tropicalis [Reaction:R-XTR-9861616] DLD dimer dehydrogenates dihydrolipoyl - Xenopus tropicalis [Reaction:R-XTR-9012016] FAHD1 dimer hydrolyses OA to PYR - Xenopus tropicalis [Reaction:R-XTR-9012268] ME2 tetramer decarboxylates MAL to PYR - Xenopus tropicalis [Reaction:R-XTR-9012349] ME3 tetramer decarboxylates MAL to PYR - Xenopus tropicalis
regulatedBy	[NegativeRegulation:10726441] Negative regulation by 'p-lipo-PDH [mitochondrial matrix]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9861734
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9861559] PDH complex synthesizes acetyl-CoA from PYR
(precedingEvent)	[Reaction:R-XTR-9861667] DLAT trimer transfers acetyl to CoA
(inferredTo)	[Reaction:R-HSA-9861734] PDH E1 decarboxylates PYR, transferring acetyl to DLAT