Reactome | PDH complex synthesizes acetyl-CoA from PYR

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PDH complex synthesizes acetyl-CoA from PYR Show undefined attributes

compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10731520
displayName	PDH complex synthesizes acetyl-CoA from PYR
eventOf	[Pathway:R-XTR-70268] Pyruvate metabolism - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:14983] pyruvate decarboxylation to acetyl-CoA
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-9861734] PDH E1 decarboxylates PYR, transferring acetyl to DLAT - Xenopus tropicalis [Reaction:R-XTR-9861667] DLAT trimer transfers acetyl to CoA - Xenopus tropicalis [Reaction:R-XTR-9861616] DLD dimer dehydrogenates dihydrolipoyl - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-9861559] PDH complex synthesizes acetyl-CoA from PYR - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	PDH complex synthesizes acetyl-CoA from PYR
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9861559
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-70268] Pyruvate metabolism
(inferredTo)	[Pathway:R-HSA-9861559] PDH complex synthesizes acetyl-CoA from PYR

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