Reactome | AFG3L2 degrades mitochondrial inner membrane proteins

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AFG3L2 degrades mitochondrial inner membrane proteins Show undefined attributes

catalystActivity	[CatalystActivity:10725591] ATP-dependent peptidase activity of AFG3L2:substrate protein (mitochondrial inner membrane) [mitochondrial inner membrane]
category	omitted
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10725593
displayName	AFG3L2 degrades mitochondrial inner membrane proteins
eventOf	[Pathway:R-XTR-9837999] Mitochondrial protein degradation - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9839113] AFG3L2 degrades mitochondrial inner membrane proteins - Homo sapiens
input	[Complex:R-XTR-9838615] AFG3L2:substrate protein (mitochondrial inner membrane) [mitochondrial inner membrane] [SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	AFG3L2 degrades mitochondrial inner membrane proteins
output	[SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] [Complex:R-XTR-9838620] AFG3L2:Zn2+ hexamer [mitochondrial inner membrane] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
precedingEvent	[Reaction:R-XTR-9838627] AFG3L2 binds mitochondrial inner membrane proteins - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9839113
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9837999] Mitochondrial protein degradation
(inferredTo)	[BlackBoxEvent:R-HSA-9839113] AFG3L2 degrades mitochondrial inner membrane proteins

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