Reactome | Factor I inactivates Factor H-boundC3b

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Factor I inactivates Factor H-boundC3b Show undefined attributes

catalystActivity	[CatalystActivity:10679408] serine-type endopeptidase activity of CFI:CFH,FHR3:C3b [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10679410
displayName	Factor I inactivates Factor H-boundC3b
eventOf	[Pathway:R-XTR-977606] Regulation of Complement cascade - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-977371] Factor I inactivates Factor H-boundC3b - Homo sapiens
input	[Complex:R-XTR-977365] CFI:CFH,FHR3:C3b [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Factor I inactivates Factor H-boundC3b
output	[Complex:R-XTR-8852842] CFI:CFH,FHR3:iC3b [plasma membrane] [DefinedSet:R-XTR-976779-3] Homologues of C3f [extracellular region]
precedingEvent	[Reaction:R-XTR-977359] Complement factor I binds to membrane-associated Factor H:C3b - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-977371
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-977606] Regulation of Complement cascade
(inferredTo)	[Reaction:R-HSA-977371] Factor I inactivates Factor H-boundC3b

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