Reactome | Complement factor I binds to membrane-associated Factor H:C3b

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Complement factor I binds to membrane-associated Factor H:C3b Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10679374
displayName	Complement factor I binds to membrane-associated Factor H:C3b
eventOf	[Pathway:R-XTR-977606] Regulation of Complement cascade - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-977371] Factor I inactivates Factor H-boundC3b - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-977359] Complement factor I binds to membrane-associated Factor H:C3b - Homo sapiens
input	[Complex:R-XTR-977596] Cell surface:FH,FHR3:C3b [plasma membrane] [Complex:R-XTR-976749] CFI [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Complement factor I binds to membrane-associated Factor H:C3b
output	[Complex:R-XTR-977365] CFI:CFH,FHR3:C3b [plasma membrane]
precedingEvent	[Reaction:R-XTR-976801] Complement factor I complex formation - Xenopus tropicalis [Reaction:R-XTR-981728] Factor H binds to membrane-associated C3b - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-977359
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-977606] Regulation of Complement cascade
(precedingEvent)	[Reaction:R-XTR-977371] Factor I inactivates Factor H-boundC3b
(inferredTo)	[Reaction:R-HSA-977359] Complement factor I binds to membrane-associated Factor H:C3b

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