Reactome | CYP2E1 monooxygenates APAP to NAPQI

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CYP2E1 monooxygenates APAP to NAPQI Show undefined attributes

catalystActivity	[CatalystActivity:10720587] monooxygenase activity of CYP2E1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10723814
displayName	CYP2E1 monooxygenates APAP to NAPQI
eventOf	[Pathway:R-XTR-9753281] Paracetamol ADME - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-9753280] GSTs transfer GSH to NAPQI to form APAP-SG - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-9753285] CYP2E1 monooxygenates APAP to NAPQI - Homo sapiens
input	[ChemicalDrug:R-ALL-9677362] APAP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP2E1 monooxygenates APAP to NAPQI CYP2E1 oxidizes APAP to NAPQI
output	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol] [SimpleEntity:R-ALL-9753466] NAPQI [cytosol]
regulatedBy	[PositiveRegulation:9753626] Positive regulation by 'isoniazid [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9753285
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9753281] Paracetamol ADME
(precedingEvent)	[Reaction:R-XTR-9753280] GSTs transfer GSH to NAPQI to form APAP-SG
(inferredTo)	[Reaction:R-HSA-9753285] CYP2E1 monooxygenates APAP to NAPQI

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